三结构域蛋白与先天免疫调控。

Tripartite-motif proteins and innate immune regulation.

机构信息

Division of Immunoregulation, MRC National Institute for Medical Research, The Ridgeway, Mill Hill, London, NW7 1AA, UK.

出版信息

Curr Opin Immunol. 2011 Feb;23(1):46-56. doi: 10.1016/j.coi.2010.10.021. Epub 2010 Dec 3.

DOI:10.1016/j.coi.2010.10.021

PMID:21131187

Abstract

The tripartite motif containing (TRIM) proteins are a family of proteins that have been implicated in many biological processes including cell differentiation, apoptosis, transcriptional regulation and signaling pathways. Many TRIM proteins are upregulated by the immunologically important Type I and Type II interferons and several, including TRIM5α and TRIM19/PML, restrict viral replication. There is growing evidence that TRIMs also play an important role in the broader immune response through regulating signaling pathways such as the RIG-I pathway. In this review we discuss recent research elucidating TRIM regulation of a number of pathways important in immunity and review the latest findings relating to viral restriction by TRIMs.

摘要

三结构域包含 (TRIM) 蛋白家族是一类参与多种生物学过程的蛋白，包括细胞分化、凋亡、转录调控和信号通路。许多 TRIM 蛋白受免疫重要的 I 型和 II 型干扰素上调，包括 TRIM5α 和 TRIM19/PML，限制病毒复制。越来越多的证据表明，TRIM 还通过调节 RIG-I 途径等信号通路，在更广泛的免疫反应中发挥重要作用。在这篇综述中，我们讨论了最近阐明 TRIM 调节免疫中许多重要途径的研究，并回顾了与 TRIM 限制病毒相关的最新发现。