State University of New York Downstate Medical Center, Brooklyn, NY, USA.
J Antimicrob Chemother. 2011 Feb;66(2):332-4. doi: 10.1093/jac/dkq459. Epub 2010 Dec 3.
Multidrug-resistant Acinetobacter baumannii and Pseudomonas aeruginosa have become a global problem, often leaving the polymyxins as therapeutic agents of last resort. ACHN-490, a next-generation aminoglycoside with activity against a broad range of Gram-positive and Gram-negative pathogens, was examined against clinical isolates of A. baumannii and P. aeruginosa.
The activity of aminoglycosides and ACHN-490 was determined against a contemporary collection of A. baumannii and P. aeruginosa. Selected aminoglycoside-resistant isolates were screened for the presence of genes encoding common aminoglycoside-modifying enzymes and methylases.
Resistance to the traditional aminoglycosides was common in the collection of A. baumannii. ACHN-490 possessed superior activity against these isolates, with an MIC(50) value of 8 mg/L. In P. aeruginosa, the activity of ACHN-490 was similar to that of amikacin (MIC(50) value of 8 mg/L for both agents). For both A. baumannii and P. aeruginosa, the MICs of ACHN-490 did not correlate with the presence of commonly encountered aminoglycoside-modifying enzymes.
For A. baumannii, the MICs of ACHN-490 were lower than those of traditional aminoglycosides. For P. aeruginosa, the activity of ACHN-490 was similar to that of amikacin.
耐多药鲍曼不动杆菌和铜绿假单胞菌已成为全球性问题，经常将多黏菌素类药物作为最后的治疗手段。ACHN-490 是一种具有广泛抗革兰氏阳性和革兰氏阴性病原体活性的新一代氨基糖苷类药物，对临床分离的鲍曼不动杆菌和铜绿假单胞菌进行了检测。
对氨基糖苷类药物和 ACHN-490 对当代鲍曼不动杆菌和铜绿假单胞菌的活性进行了测定。对选定的氨基糖苷类耐药分离株进行了常见氨基糖苷类修饰酶和甲基化酶编码基因的筛选。
在收集的鲍曼不动杆菌中，对传统氨基糖苷类药物的耐药性很常见。ACHN-490 对这些分离株具有优越的活性，MIC（50）值为 8mg/L。在铜绿假单胞菌中，ACHN-490 的活性与阿米卡星相似（两者的 MIC（50）值均为 8mg/L）。对于鲍曼不动杆菌和铜绿假单胞菌，ACHN-490 的 MIC 与常见的氨基糖苷类修饰酶无关。
对于鲍曼不动杆菌，ACHN-490 的 MIC 低于传统氨基糖苷类药物。对于铜绿假单胞菌，ACHN-490 的活性与阿米卡星相似。
