白色念珠菌高渗甘油（HOG）途径与对人β-防御素2和3的反应之间的相互作用。
Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
作者信息
Argimón Silvia, Fanning Saranna, Blankenship Jill R, Mitchell Aaron P
机构信息
Department of Microbiology, Columbia University, New York, New York 10032, USA.
出版信息
Eukaryot Cell. 2011 Feb;10(2):272-5. doi: 10.1128/EC.00133-10. Epub 2010 Dec 3.
Abstract
Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.
摘要
人β-防御素2和3是对真菌病原体白色念珠菌具有抗菌活性的小阳离子肽。我们发现，hog1和pbs2突变体对这些肽的处理高度敏感，这表明高渗甘油（HOG）途径在对防御素诱导的细胞损伤的反应中起作用。
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