白色念珠菌高渗甘油（HOG）途径与对人β-防御素2和3的反应之间的相互作用。
Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
作者信息
Argimón Silvia, Fanning Saranna, Blankenship Jill R, Mitchell Aaron P
机构信息
Department of Microbiology, Columbia University, New York, New York 10032, USA.
出版信息
Eukaryot Cell. 2011 Feb;10(2):272-5. doi: 10.1128/EC.00133-10. Epub 2010 Dec 3.
Abstract
Human β-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.
摘要
人β-防御素2和3是对真菌病原体白色念珠菌具有抗菌活性的小阳离子肽。我们发现，hog1和pbs2突变体对这些肽的处理高度敏感，这表明高渗甘油（HOG）途径在对防御素诱导的细胞损伤的反应中起作用。
相似文献
1
Interaction between the Candida albicans high-osmolarity glycerol (HOG) pathway and the response to human beta-defensins 2 and 3.
Eukaryot Cell. 2011 Feb;10(2):272-5. doi: 10.1128/EC.00133-10. Epub 2010 Dec 3.
2
Identification and mechanism of action of the plant defensin NaD1 as a new member of the antifungal drug arsenal against Candida albicans.
Antimicrob Agents Chemother. 2013 Aug;57(8):3667-75. doi: 10.1128/AAC.00365-13. Epub 2013 May 20.
3
Distinct antifungal mechanisms: beta-defensins require Candida albicans Ssa1 protein, while Trk1p mediates activity of cysteine-free cationic peptides.
Antimicrob Agents Chemother. 2006 Jan;50(1):324-31. doi: 10.1128/AAC.50.1.324-331.2006.
4
Inhibitory effect of berberine hydrochloride against Candida albicans and the role of the HOG-MAPK pathway.
J Antibiot (Tokyo). 2021 Nov;74(11):807-816. doi: 10.1038/s41429-021-00463-w. Epub 2021 Aug 19.
5
Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway.
Eukaryot Cell. 2007 Oct;6(10):1876-88. doi: 10.1128/EC.00039-07. Epub 2007 Aug 22.
6
Candida albicans mucin Msb2 is a broad-range protectant against antimicrobial peptides.
Antimicrob Agents Chemother. 2013 Aug;57(8):3917-22. doi: 10.1128/AAC.00862-13. Epub 2013 Jun 3.
7
The antifungal plant defensin RsAFP2 from radish induces apoptosis in a metacaspase independent way in Candida albicans.
FEBS Lett. 2009 Aug 6;583(15):2513-6. doi: 10.1016/j.febslet.2009.07.004. Epub 2009 Jul 14.
8
The radish defensins RsAFP1 and RsAFP2 act synergistically with caspofungin against Candida albicans biofilms.
Peptides. 2016 Jan;75:71-9. doi: 10.1016/j.peptides.2015.11.001. Epub 2015 Nov 28.
9
Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3.
Antimicrob Agents Chemother. 2009 Jan;53(1):256-60. doi: 10.1128/AAC.00470-08. Epub 2008 Sep 22.
10
Defensins from insects and plants interact with fungal glucosylceramides.
J Biol Chem. 2004 Feb 6;279(6):3900-5. doi: 10.1074/jbc.M311165200. Epub 2003 Nov 6.
引用本文的文献
1
The Contribution of Human Antimicrobial Peptides to Fungi.
Int J Mol Sci. 2025 Mar 11;26(6):2494. doi: 10.3390/ijms26062494.
2
Antifungal Synergy: Mechanistic Insights into the R-1-R Peptide and Extract as Potent Therapeutics against spp. through Proteomics.
Int J Mol Sci. 2024 Aug 16;25(16):8938. doi: 10.3390/ijms25168938.
3
Antimicrobial Peptides with Anti- Activity.
Int J Mol Sci. 2022 Aug 17;23(16):9264. doi: 10.3390/ijms23169264.
4
Antimicrobial Activity of the Peptide LfcinB15 against .
J Fungi (Basel). 2021 Jun 29;7(7):519. doi: 10.3390/jof7070519.
5
Protein-Protein Interactions in .
Front Microbiol. 2019 Aug 7;10:1792. doi: 10.3389/fmicb.2019.01792. eCollection 2019.
6
Stress-Activated Protein Kinases in Human Fungal Pathogens.
Front Cell Infect Microbiol. 2019 Jul 17;9:261. doi: 10.3389/fcimb.2019.00261. eCollection 2019.
7
" Interactions With The Host: Crossing The Intestinal Epithelial Barrier".
Tissue Barriers. 2019;7(2):1612661. doi: 10.1080/21688370.2019.1612661. Epub 2019 Jun 12.
8
Fungal Strategies to Evade the Host Immune Recognition.
J Fungi (Basel). 2017 Sep 23;3(4):51. doi: 10.3390/jof3040051.
9
Fungi that Infect Humans.
Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.FUNK-0014-2016.
10
Oropharyngeal Candidiasis: Fungal Invasion and Epithelial Cell Responses.
PLoS Pathog. 2017 Jan 12;13(1):e1006056. doi: 10.1371/journal.ppat.1006056. eCollection 2017 Jan.
本文引用的文献
1
An extensive circuitry for cell wall regulation in Candida albicans.
PLoS Pathog. 2010 Feb 5;6(2):e1000752. doi: 10.1371/journal.ppat.1000752.
2
Detection of protein-protein interactions through vesicle targeting.
Genetics. 2009 May;182(1):33-9. doi: 10.1534/genetics.109.101162. Epub 2009 Mar 23.
3
Antifungal activities of human beta-defensins HBD-1 to HBD-3 and their C-terminal analogs Phd1 to Phd3.
Antimicrob Agents Chemother. 2009 Jan;53(1):256-60. doi: 10.1128/AAC.00470-08. Epub 2008 Sep 22.
4
Regulation of the Candida albicans cell wall damage response by transcription factor Sko1 and PAS kinase Psk1.
Mol Biol Cell. 2008 Jul;19(7):2741-51. doi: 10.1091/mbc.e08-02-0191. Epub 2008 Apr 23.
5
Therapeutic potential of antifungal plant and insect defensins.
Drug Discov Today. 2007 Nov;12(21-22):966-71. doi: 10.1016/j.drudis.2007.07.016. Epub 2007 Sep 4.
6
Requirement for Candida albicans Sun41 in biofilm formation and virulence.
Eukaryot Cell. 2007 Nov;6(11):2046-55. doi: 10.1128/EC.00314-07. Epub 2007 Sep 14.
7
A single MAPKKK regulates the Hog1 MAPK pathway in the pathogenic fungus Candida albicans.
Mol Biol Cell. 2007 Nov;18(11):4603-14. doi: 10.1091/mbc.e07-06-0581. Epub 2007 Sep 5.
8
Histatin 5 initiates osmotic stress response in Candida albicans via activation of the Hog1 mitogen-activated protein kinase pathway.
Eukaryot Cell. 2007 Oct;6(10):1876-88. doi: 10.1128/EC.00039-07. Epub 2007 Aug 22.
9
Human beta-defensins kill Candida albicans in an energy-dependent and salt-sensitive manner without causing membrane disruption.
Antimicrob Agents Chemother. 2007 Jan;51(1):154-61. doi: 10.1128/AAC.00478-06. Epub 2006 Oct 30.
10
Role of the Hog1 stress-activated protein kinase in the global transcriptional response to stress in the fungal pathogen Candida albicans.
Mol Biol Cell. 2006 Feb;17(2):1018-32. doi: 10.1091/mbc.e05-06-0501. Epub 2005 Dec 7.
Zotero 插件