Krishnakumari Viswanatha, Rangaraj Nandini, Nagaraj Ramakrishnan
Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India.
Antimicrob Agents Chemother. 2009 Jan;53(1):256-60. doi: 10.1128/AAC.00470-08. Epub 2008 Sep 22.
The activities of defensins HBD-1, HBD-2, and HBD-3 and their C-terminal analogs Phd1, Phd2, and Phd3 against Candida albicans were investigated. Phd1 to Phd3 showed lower-level activities than HBD-1 to HBD-3, although metabolic inhibitors did not render Phd1 to Phd3 inactive. Their activities were also less salt sensitive than those of HBD-1 to HBD-3. Confocal microscope images indicated that the initial site of action was the fungal membrane.
研究了防御素HBD - 1、HBD - 2和HBD - 3及其C末端类似物Phd1、Phd2和Phd3对白色念珠菌的活性。尽管代谢抑制剂并未使Phd1至Phd3失活,但Phd1至Phd3的活性低于HBD - 1至HBD - 3。它们的活性对盐的敏感性也低于HBD - 1至HBD - 3。共聚焦显微镜图像表明,作用的初始位点是真菌膜。