Jadali Zohreh, Alavian Seyed-Moayed
Department of Immunology, School of Public Health, Tehran University of Medical Sciences. Tehran, Iran.
Iran J Allergy Asthma Immunol. 2010 Dec;9(4):191-206.
Autoimmunity and viral infections are closely associated fields, and viruses have been proposed as a likely aetiological, contributory or triggering factors of systemic autoimmune diseases. Hepatitis C virus seems to be the virus usually associated with the appearance of autoimmune diseases, and the relationship between chronic hepatitis C virus infection and some autoimmune disease has been studied. For some of these disorders their association with hepatitis C virus infection is well recognized while for others it remains probable or weak. Examples of autoimmune phenomena observed in chronic hepatitis C virus infection include rheumatoid arthritis, thyroid disease, cryoglobulinaemia, immune thrombocytopenic purpura, systemic lupus erythematosus and sjogren syndrome. To date, the etiological role and the pathogenetic involvement of the hepatitis C infection remains unknown.The aim of this study is to assess the presence of different autoimmune manifestations of hepatitis C virus infection reported in literature.
自身免疫与病毒感染是密切相关的领域，病毒被认为可能是系统性自身免疫性疾病的病因、促成因素或触发因素。丙型肝炎病毒似乎是通常与自身免疫性疾病出现相关的病毒，并且慢性丙型肝炎病毒感染与某些自身免疫性疾病之间的关系已得到研究。对于其中一些疾病，它们与丙型肝炎病毒感染的关联已得到充分认识，而对于其他疾病，这种关联仍可能存在或较弱。在慢性丙型肝炎病毒感染中观察到的自身免疫现象包括类风湿性关节炎、甲状腺疾病、冷球蛋白血症、免疫性血小板减少性紫癜、系统性红斑狼疮和干燥综合征。迄今为止，丙型肝炎感染的病因学作用和发病机制仍不清楚。本研究的目的是评估文献中报道的丙型肝炎病毒感染的不同自身免疫表现的存在情况。
