Department of Surgical Oncology, Institute of Medical Sciences, Faculty of Science, Banaras Hindu University, Varanasi, Uttar Pradesh, India.
Eur J Cancer Prev. 2011 Mar;20(2):77-85. doi: 10.1097/CEJ.0b013e328341e371.
Gallbladder cancer (GBC) is the most common malignancy of the biliary tract. Despite the recent advancements in the understanding of cancer biology the disease still remains a therapeutic challenge with poor survival, and with early surgical resection as the only powerful treatment. Understanding the molecular events in gallbladder carcinogenesis may provide a novel targeted therapeutic approach. Of these, alterations in the tumour suppressor gene, p53, are commonly observed in most human cancers. However, its impact on the pathogenesis of GBC remains obscure. This study attempts to outline the p53 structure, function and its alterations, with special attention to GBC.
胆囊癌（GBC）是胆道系统最常见的恶性肿瘤。尽管近年来对癌症生物学的认识有了进步，但该病仍然是一个治疗挑战，生存情况较差，早期手术切除是唯一有效的治疗方法。了解胆囊癌发生过程中的分子事件可能为新的靶向治疗方法提供依据。在这些事件中，肿瘤抑制基因 p53 的改变在大多数人类癌症中都很常见。然而，其对 GBC 发病机制的影响尚不清楚。本研究试图概述 p53 的结构、功能及其改变，特别关注 GBC。
