Department of Cellular Pathology, Birmingham Women's Hospital, Birmingham, UK.
Int J Gynecol Pathol. 2011 Jan;30(1):46-52. doi: 10.1097/PGP.0b013e3181eaa1ff.
The eutopic location of ovarian hilus cells in the hilar stroma of the ovary and in the adjacent mesovarium is widely recognized. Hilus cell heterotopia, that is, the presence of normal hilus cells in an abnormal site, is rare and there are only a few case reports and 1 earlier systematic study of this phenomenon in the literature. Hilus cell heterotopia has been reported in the fimbrial stroma of the fallopian tube, paratubal and parafimbrial cyst walls and usually takes the form of discrete, circumscribed nodules or clusters of hilus cells. We report a series of 6 cases of hilus cell heterotopia, all of which were identified in association with other underlying pelvic pathology and in patients over 40 years of age. We have shown that hilus cell heterotopia is not limited to the fallopian tube but can also involve the subcapsular ovarian cortex and may have an infiltrative (rather than a nested) growth pattern that can resemble metastatic carcinoma, potentially mimicking a metastatic lobular carcinoma of the breast. This is particularly relevant in patients in whom staging procedures are carried out for gynecologic pelvic neoplasms, and for those few patients who also have a history of concurrent carcinoma, particularly of the breast.
卵巢门细胞位于卵巢门基质和邻近的阔韧带中，这是广泛认可的。门细胞异位，即正常门细胞出现在异常部位，是罕见的，文献中仅有少数病例报告和 1 项对此现象的早期系统研究。门细胞异位已在输卵管的伞部基质、副输卵管和副输卵管旁囊肿壁中报道，通常表现为离散的、界限清楚的结节或门细胞簇。我们报告了 6 例门细胞异位病例，均与其他盆腔基础病变相关，且患者年龄均大于 40 岁。我们表明，门细胞异位不仅限于输卵管，还可累及卵巢皮质的包膜下区，并且可能具有浸润性（而非巢状）生长模式，类似于转移性癌，可能模拟转移性乳腺小叶癌。这在为妇科盆腔肿瘤进行分期程序的患者中尤为相关，对于那些少数同时患有癌的患者，尤其是乳腺癌患者，也是如此。
