The Pennsylvania State University, University Park, USA.
Ann Behav Med. 2011 Apr;41(2):208-26. doi: 10.1007/s12160-010-9253-x.
The multiphase optimization strategy (MOST) is a new methodological approach for building, optimizing, and evaluating multicomponent interventions. Conceptually rooted in engineering, MOST emphasizes efficiency and careful management of resources to move intervention science forward steadily and incrementally. MOST can be used to guide the evaluation of research evidence, develop an optimal intervention (the best set of intervention components), and enhance the translation of research findings, particularly type II translation. This article uses an ongoing study to illustrate the application of MOST in the evaluation of diverse intervention components derived from the phase-based framework reviewed in the companion article by Baker et al. (Ann Behav Med, in press, 2011). The article also discusses considerations, challenges, and potential benefits associated with using MOST and similar principled approaches to improving intervention efficacy, effectiveness, and cost-effectiveness. The applicability of this methodology may extend beyond smoking cessation to the development of behavioral interventions for other chronic health challenges.
多阶段最优化策略（MOST）是一种新的方法学方法，用于构建、优化和评估多成分干预措施。MOST 概念上根植于工程学，强调效率和资源的精心管理，以稳步、逐步地推动干预科学的发展。MOST 可用于指导研究证据的评估、开发最佳干预措施（最佳干预成分组合），并促进研究结果的转化，特别是第二类型的转化。本文使用正在进行的一项研究，说明了 MOST 在评估源自贝克尔等人（Ann Behav Med，in press, 2011）综述的基于阶段框架的不同干预成分中的应用。本文还讨论了使用 MOST 和类似有原则的方法来提高干预效果、有效性和成本效益的相关考虑因素、挑战和潜在益处。这种方法的适用性可能不仅限于戒烟，还可以扩展到开发针对其他慢性健康挑战的行为干预措施。
