West Midlands Perinatal Institute, Aston Cross, Birmingham, UK.
Paediatr Perinat Epidemiol. 2011 Jan;25(1):2-10. doi: 10.1111/j.1365-3016.2010.01166.x. Epub 2010 Oct 18.
Customised centiles based on individual fetal growth potential enhance our ability to differentiate between physiological and pathological smallness. A series of studies in different maternity populations has found striking similarities in the way fetal growth varies with maternal and pregnancy related characteristics, and has established the clear advantages of this method over generic, population-based birthweight or fetal weight standards. The method opens up many new avenues for the retrospective study of risk factors and fetal growth. The findings quantify the strength of association between fetal growth restriction and perinatal outcome, and therefore also highlight the clinical imperative to improve antenatal detection of the at-risk fetus. Applied prospectively as customised charts, the concept improves the detection of fetal growth restriction and reduces the need for unnecessary investigations.
基于个体胎儿生长潜能的定制百分位数可提高我们区分生理和病理生长受限的能力。一系列在不同孕产妇人群中进行的研究发现，胎儿生长与母亲和妊娠相关特征的变化方式具有惊人的相似性，并证实了这种方法优于通用的基于人群的出生体重或胎儿体重标准的明显优势。该方法为危险因素和胎儿生长的回顾性研究开辟了许多新途径。研究结果量化了胎儿生长受限与围产儿结局之间的关联强度，因此也凸显了提高产前高危胎儿检出率的临床必要性。前瞻性地应用定制图表，该概念可提高胎儿生长受限的检出率并减少不必要的检查。
