脑促甲状腺激素释放激素（TRH）在大鼠应激性胃损伤形成中作用的证据。

Evidence for a role of brain thyrotropin-releasing hormone (TRH) on stress gastric lesion formation in rats.

作者信息

Hernandez D E, Arredondo M E, Xue B G, Jennes L

机构信息

Division of Gastroenterology, University of Southern California, Los Angeles 90033.

出版信息

Brain Res Bull. 1990 May;24(5):693-5. doi: 10.1016/0361-9230(90)90009-o.

DOI:10.1016/0361-9230(90)90009-o

Abstract

Specific polyclonal antibodies raised against synthetic thyrotropin-releasing hormone (TRH) infused intracerebroventricularly (ICV) significantly decreased gastric lesions induced by cold restraint stress. The antiulcer effect of immunologic blockade of brain TRH was specific. Normal rabbit serum or antibodies raised against somatostatin, alpha-MSH, Leu-enkephalin, gonadotropin-releasing hormone and atrial natriuretic factor were ineffective. These findings suggest that brain TRH may play an important role in experimental stress ulcer formation.

摘要

针对经脑室内注射（ICV）的合成促甲状腺激素释放激素（TRH）产生的特异性多克隆抗体，可显著减少冷束缚应激诱导的胃部损伤。脑TRH免疫阻断的抗溃疡作用具有特异性。正常兔血清或针对生长抑素、α-促黑素、亮氨酸脑啡肽、促性腺激素释放激素和心钠素产生的抗体均无效。这些发现表明，脑TRH可能在实验性应激性溃疡形成中起重要作用。

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