Caggiula A R, Stoney C M, Matthews K A, Owens J F, Davis M C, Rabin B S
Department of Psychiatry, University of Pittsburgh School of Medicine, Pennsylvania.
Clin Immunol Immunopathol. 1990 Jul;56(1):130-4. doi: 10.1016/0090-1229(90)90177-r.
Reactivity of blood lymphocytes to nonspecific mitogenic stimulation with phytohemagglutinin (PHA) was measured in nine healthy, regularly cycling women at three phases of their menstrual cycles corresponding to peak levels of estradiol (midfollicular phase), peak levels of progesterone (midluteal phase), and the lowest levels of both hormones (menstrual phase). Sampling points were verified by radioimmunoassay of estrogen, progesterone, luteinizing hormone, and follicle-stimulating hormone. There were significant increases in reactivity associated with an increasing concentration of PHA and with autologous plasma vs AB plasma. However, no differences were found in reactivity to PHA over the three menstrual cycle phases and correlational analyses indicated no relationship between counts and any of the hormones measured.
在9名月经周期规律的健康女性的月经周期的三个阶段，即对应雌二醇峰值水平的卵泡中期、对应孕酮峰值水平的黄体中期以及两种激素水平均最低的月经期，测量了血液淋巴细胞对植物血凝素（PHA）非特异性促有丝分裂刺激的反应性。通过对雌激素、孕酮、促黄体生成素和促卵泡激素进行放射免疫测定来验证采样点。随着PHA浓度的增加以及与自体血浆相比AB血浆，反应性有显著增加。然而，在三个月经周期阶段对PHA的反应性未发现差异，相关性分析表明细胞计数与所测任何激素之间均无关系。
