Sutker P B, Goist K C, King A R
Alcohol Clin Exp Res. 1987 Feb;11(1):74-9. doi: 10.1111/j.1530-0277.1987.tb01266.x.
This study investigated relationships between metabolic responses to acute alcohol intoxication and phases of the female menstrual cycle among women demonstrated to have ovulated during two consecutive cycles. Subjects were administered moderate (0.66 ml/kg) and high (1.0 ml/kg) alcohol doses during the early follicular, ovulatory, and midluteal phases of the menstrual cycles. Radioimmunoassays (RIAs) of serum estradiol, progesterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels were performed from blood collected before each alcohol administration. Results showed decreased elimination times, reduced areas under the BAC-time curve (AUCs), and faster disappearance rates associated with the midluteal menstrual phase compared to the early follicular and ovulatory phases which were consistent for both moderate and high alcohol doses. Decreased elimination times, smaller AUCs, and faster disappearance rates were associated with increased levels of progesterone, elevated progesterone to estradiol ratios, and decreased FSH levels. No differences were found in absorption time or peak BAC across phases of the menstrual cycle.
本研究调查了在连续两个周期中已排卵的女性，急性酒精中毒的代谢反应与女性月经周期各阶段之间的关系。在月经周期的卵泡早期、排卵期和黄体中期，给受试者分别服用中等剂量（0.66毫升/千克）和高剂量（1.0毫升/千克）的酒精。在每次酒精给药前采集的血液中，对血清雌二醇、孕酮、促黄体生成素（LH）和促卵泡生成素（FSH）水平进行放射免疫测定（RIA）。结果显示，与卵泡早期和排卵期相比，黄体中期月经阶段的消除时间缩短、血液酒精浓度-时间曲线下面积（AUC）减小、消失速率加快，中等剂量和高剂量酒精的情况均如此。消除时间缩短、AUC减小和消失速率加快与孕酮水平升高、孕酮与雌二醇比值升高以及FSH水平降低有关。在月经周期各阶段的吸收时间或血液酒精浓度峰值方面未发现差异。
