Interdisciplinary Research Organization, University of Miyazaki, 1-1 Gakuenkibanadai-nishi, Miyazaki 889-2192, Japan.
Fish Shellfish Immunol. 2011 Nov;31(5):635-43. doi: 10.1016/j.fsi.2010.11.028. Epub 2010 Dec 4.
Interleukin-17 (IL-17) is a cytokine family composed of six ligands (A-F). Especially, the IL-17A and IL-17F are best characterized cytokines of IL-17 family cytokine. These are produced by Th17 cells and induce the expression of many mediators of inflammation properties. In addition, the five member of IL-17 receptor family (RA-RE) have been identified in mammals. Although the research on fish IL-17 is a little to date, this review discusses some of the recent advances in research on IL-17 ligand and receptor genes in fish. IL-17 family member was chosen from the fish genome database, and its structure and phylogeny is analyzed in detail. Moreover, invertebrate IL-17 genes are also discussed, and the isolation and current status of fish IL-17 receptor genes are summarized. Comparative genomic analysis of the IL-17 family among mammals, teleost and invertebrates provided new insights. Novel IL-17 ligand (IL-17N) was identified from teleost, moreover it was suggested that IL-17N may be a teleost specific ligand by synteny and phylogenetic analysis. On the other hand, IL-17 receptors are well conserved between mammal and teleost, the five member of IL-17 receptor family: IL-17RA-RE were found on the teleost genome. In addition, the IL-17RA gene was duplicated in tandem on the stickleback and medaka genome. Knowledge about the IL-17 ligand/receptor in fish is very limited. Therefore this review will hopefully encourage future studies of IL-17 in fish.
白细胞介素-17 (IL-17) 是一种细胞因子家族，由六种配体 (A-F) 组成。特别是，IL-17A 和 IL-17F 是 IL-17 家族细胞因子中特征最好的细胞因子。这些细胞因子由 Th17 细胞产生，并诱导许多炎症介质的表达。此外，哺乳动物中已经鉴定出五个白细胞介素-17 受体家族成员 (RA-RE)。尽管鱼类 IL-17 的研究还比较少，但本综述讨论了鱼类 IL-17 配体和受体基因研究的一些最新进展。从鱼类基因组数据库中选择了 IL-17 家族成员，详细分析了其结构和系统发育。此外，还讨论了无脊椎动物的 IL-17 基因，并总结了鱼类 IL-17 受体基因的分离和现状。哺乳动物、硬骨鱼和无脊椎动物之间的 IL-17 家族比较基因组分析提供了新的见解。从硬骨鱼中鉴定出了新型白细胞介素-17 配体 (IL-17N)，通过基因同线性和系统发育分析表明，IL-17N 可能是硬骨鱼特有的配体。另一方面，IL-17 受体在哺乳动物和硬骨鱼之间高度保守，在硬骨鱼基因组中发现了五个白细胞介素-17 受体家族成员：IL-17RA-RE。此外，IL-17RA 基因在棘鱼和斑马鱼基因组中串联重复。鱼类中关于 IL-17 配体/受体的知识非常有限。因此，本综述将有望鼓励未来对鱼类 IL-17 的研究。
