Pirkanmaa Hospital District, Tampere, Finland.
Prim Care Diabetes. 2010 Dec;4(4):231-9. doi: 10.1016/j.pcd.2010.05.005. Epub 2010 Jun 18.
To study screening of high-risk individuals as part of a national diabetes prevention programme in primary health care settings in Finland between 2003 and 2007, and evaluate the cardiometabolic risk profile of persons identified for intervention.
High-risk individuals were identified by the Finnish Diabetes Risk Score (FINDRISC), history of impaired fasting glucose (IFG), impaired glucose tolerance (IGT), cardiovascular disease (CVD), or gestational diabetes. Participants subsequently underwent an oral glucose tolerance test. CVD morbidity risk was estimated by the Framingham Study Risk Equation and CVD mortality risk by the Systematic Coronary Risk Evaluation Formula (SCORE).
A high-risk cohort of 10,149 (of whom 30.3% men) was identified (mean age 54.7 for men, 53.0 for women). Altogether 18.8% of men and 11.5% of women had screen-detected diabetes. In total 68.1% of men and 49.4% of women had abnormal glucose tolerance (IFG, IGT or screen-detected diabetes). Furthermore, 43.2% and 41.5% of men, and 13.3% and 11.3% of women, respectively, had a high predicted risk of CVD morbidity or mortality.
Prevalence of dysglycemia including undiagnosed diabetes and the predicted risk for CVD was alarmly high in the identified high-risk cohort, particularly in men.
研究 2003 年至 2007 年期间芬兰初级卫生保健机构中作为国家糖尿病预防计划一部分的高危人群筛查，并评估为干预而确定的个体的心血管代谢风险特征。
通过芬兰糖尿病风险评分（FINDRISC）、空腹血糖受损（IFG）、葡萄糖耐量受损（IGT）、心血管疾病（CVD）或妊娠糖尿病史来识别高危人群。随后参与者接受口服葡萄糖耐量试验。通过 Framingham 研究风险方程估计 CVD 发病风险，通过系统性冠状动脉风险评估公式（SCORE）估计 CVD 死亡风险。
确定了一个高危队列，共有 10149 人（其中 30.3%为男性）（男性平均年龄为 54.7 岁，女性为 53.0 岁）。男性中有 18.8%和女性中有 11.5%的人患有经筛查发现的糖尿病。共有 68.1%的男性和 49.4%的女性存在异常葡萄糖耐量（IFG、IGT 或经筛查发现的糖尿病）。此外，分别有 43.2%和 41.5%的男性以及 13.3%和 11.3%的女性具有较高的 CVD 发病或死亡风险预测。
在确定的高危人群中，包括未诊断的糖尿病在内的糖代谢异常以及 CVD 的预测风险均非常高，尤其是在男性中。
