Department of Chemistry, UGC-Centre for Advanced Studies, Guru Nanak Dev University, Amritsar, India.
Phys Chem Chem Phys. 2012 Jan 14;14(2):887-98. doi: 10.1039/c1cp22448d. Epub 2011 Nov 25.
The mixed micellization and interfacial behavior of pyridinium gemini surfactants, 1,1'-(1,1'-(ethane-1,2-diylbis-(sulfanediyl))bis(alkane-2,1-diyl))dipyridinium bromide, i.e., [12-(S-2-S)-12], [14-(S-2-S)-14], [16-(S-2-S)-16] with a phenothiazine tranquilizer drug, promethazine hydrochloride (PMT), has been investigated by conductivity, surface tension and steady state fluorescence measurements. Different spectroscopic techniques like fluorescence, UV-visible and NMR were also employed to understand the nature of interactions between the pyridinium gemini surfactants and PMT. The various micellar, interfacial and associated thermodynamic parameters for different mole fractions of PMT-pyridinium gemini surfactant mixtures have been evaluated. Synergism was observed in the mixed micelle as well as the monolayer formed by these mixtures. The fluorescence quenching experiment indicates that the interactions between PMT and surfactants are hydrophobic in nature. The UV-visible measurements reveal the distinct formation of a drug-surfactant complex. The detailed mechanism for the type of interactions was further studied by NMR titrations which show cation-π interactions between PMT and pyridinium gemini surfactant molecules.
吡啶双子表面活性剂的混合胶束化和界面行为，1,1'-(1,1'-(乙烷-1,2-二基双(磺酰基))双(烷烃-2,1-二基))二吡啶溴化物，即[12-(S-2-S)-12]、[14-(S-2-S)-14]、[16-(S-2-S)-16]与苯并二氮杂䓬类镇静剂药物盐酸普罗米嗪 (PMT) 的混合胶束化和界面行为已通过电导率、表面张力和稳态荧光测量进行了研究。还使用了不同的光谱技术，如荧光、紫外-可见和 NMR，以了解吡啶双子表面活性剂和 PMT 之间相互作用的性质。评估了不同 PMT-吡啶双子表面活性剂混合物摩尔分数的各种胶束、界面和相关热力学参数。在这些混合物形成的混合胶束和单层中观察到协同作用。荧光猝灭实验表明 PMT 和表面活性剂之间的相互作用是疏水的。紫外-可见测量显示明显形成了药物-表面活性剂复合物。通过 NMR 滴定进一步研究了这种相互作用的详细机制，表明 PMT 和吡啶双子表面活性剂分子之间存在阳离子-π 相互作用。
