Rottenberg M E, Cardoni R L, Segura E L
Instituto Nacional de Diagnóstico e Investigación de la Enfermedad de Chagas Dr. M. Fatala Chaben, Buenos Aires, Argentina.
Int J Parasitol. 1990 May;20(3):397-400. doi: 10.1016/0020-7519(90)90158-j.
Cellular populations involved in resistance against T. cruzi infection were characterized from mice chronically infected with the parasite. Mice transfused with spleen cells (SC), nylon-wool-non-adherent spleen cells (NWNA) or sera from mice chronically infected with T. cruzi, showed an enhanced resistance against challenge with the parasite. The protective activity of NWNA but not of SC was completely abrogated by treatment with anti-Thy1.2 monoclonal antibodies (mAb) and complement (C). Pretreatment of NWNA cells from chronically infected mice with either anti-L3T4 or anti-Lyt 2.2 mAb partially reduced the transfer of resistance. When both L3T4+ and Lyt2.2+ cells were depleted from NWNA populations, transfer of resistance was abolished. These results appear to indicate that L3T4+, Lyt2.2+ T cell subsets and non-T cells are involved in the immunity to T. cruzi.
从慢性感染克氏锥虫的小鼠中鉴定出参与抵抗克氏锥虫感染的细胞群体。输注来自慢性感染克氏锥虫小鼠的脾细胞（SC）、尼龙毛非黏附脾细胞（NWNA）或血清的小鼠，对该寄生虫攻击的抵抗力增强。用抗Thy1.2单克隆抗体（mAb）和补体（C）处理后，NWNA而非SC的保护活性完全丧失。用抗L3T4或抗Lyt 2.2 mAb预处理慢性感染小鼠的NWNA细胞，可部分降低抵抗力的传递。当从NWNA群体中耗尽L3T4 +和Lyt2.2 +细胞时，抵抗力传递被消除。这些结果似乎表明，L3T4 +、Lyt2.2 + T细胞亚群和非T细胞参与了对克氏锥虫的免疫。
