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MM 45289, a potent glycopeptide antibiotic which interacts weakly with diacetyl-L-lysyl-D-alanyl-D-alanine.

作者信息

Good V M, Gwynn M N, Knowles D J

机构信息

Beecham Pharmaceuticals Research Division, Betchworth, Surrey, UK.

出版信息

J Antibiot (Tokyo). 1990 May;43(5):550-5. doi: 10.7164/antibiotics.43.550.

DOI:10.7164/antibiotics.43.550
PMID:2113517
Abstract

MM 45289 (A82846A, eremomycin), a glycopeptide antibiotic of the vancomycin type, was confirmed to have improved antibacterial activity over vancomycin. However its affinity (Ka) for the target site peptide mimetic diacetyl-L-lysyl-D-alanyl-D-alanine (DALAA) was 23-fold lower. Concentrations of DALAA required to reverse the antibacterial activity of MM 45289 were in the order of 10 to 50-fold higher than for vancomycin. These results have implications for both mode of action studies and mechanism-based screening strategies for this class of antibiotic.

摘要

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