万古霉素类抗生素细胞外靶向中的二聚化与膜锚定
Dimerization and membrane anchors in extracellular targeting of vancomycin group antibiotics.
作者信息
Beauregard D A, Williams D H, Gwynn M N, Knowles D J
机构信息
Cambridge Centre for Molecular Recognition, University Chemical Laboratory, England.
出版信息
Antimicrob Agents Chemother. 1995 Mar;39(3):781-5. doi: 10.1128/AAC.39.3.781.
Abstract
Antibiotics of the vancomycin group are shown to enhance their affinities for the bacterial cell wall by the devices of either dimerization (vancomycin and other glycopeptides which dimerize even more strongly) or use of a membrane anchor (teicoplanin); a chelate mechanism is suggested in both cases, as supported by antagonism experiments with the cell wall analog di-N-acetyl-L-Lys-D-Ala-D-Ala. These results may have implications for other binding processes which occur near membrane surfaces.
摘要
研究表明，万古霉素类抗生素可通过二聚化（万古霉素及其他二聚化作用更强的糖肽类抗生素）或使用膜锚定结构（替考拉宁）来增强其与细菌细胞壁的亲和力；两种情况下均提示存在螯合机制，这得到了细胞壁类似物二 - N - 乙酰 - L - 赖氨酸 - D - 丙氨酸 - D - 丙氨酸的拮抗实验的支持。这些结果可能对发生在膜表面附近的其他结合过程具有启示意义。
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