Mortensen K E, Revhaug A
Surgical Research Laboratory, Institute of Clinical Medicine, University of Tromsoe, Tromsoe, Norway.
Eur Surg Res. 2011;46(1):1-18. doi: 10.1159/000321361. Epub 2010 Dec 7.
METHODS/AIMS: Despite improved preoperative evaluation, surgical techniques and perioperative intensive care, some patients still experience postoperative liver failure in part due to insufficient regeneration. The aim of this review is to give the reader a historical synopsis of the major trends in animal research on liver regeneration from the early experiments in 1877 up to modern investigation. A major focus is placed on the translational value of experimental surgery.
A systematic review of the English literature published in Medline was undertaken with the search words 'pig, porcine, dog, canine, liver regeneration, experimental'.
The evolution of the various models tentatively explaining the process of liver regeneration is described.
We conclude by emphasizing the importance of large-animal surgical research on liver regeneration as it offers a more integrated, systemic biological understanding of this complex process. Furthermore, in our opinion, a closer collaboration between the hepatologist, liver surgeon/transplant surgeon and the laboratory scientist may advance clinically relevant research in liver regeneration.
方法/目的：尽管术前评估、手术技术和围手术期重症监护有所改进，但仍有部分患者术后出现肝功能衰竭，部分原因是肝再生不足。本综述的目的是向读者提供从1877年的早期实验到现代研究期间，肝脏再生动物研究主要趋势的历史概述。主要重点在于实验性手术的转化价值。
使用搜索词“猪、猪肝、狗、犬肝、肝再生、实验”对Medline上发表的英文文献进行系统综述。
描述了初步解释肝再生过程的各种模型的演变。
我们强调大型动物肝脏再生外科研究的重要性，因为它能对这一复杂过程提供更全面、系统的生物学理解。此外，我们认为肝病学家、肝脏外科医生/移植外科医生与实验室科学家之间更紧密的合作可能会推动肝再生方面具有临床相关性的研究。
