Kwon Yong Jin, Lee Kyeong Geun, Choi Dongho
Department of Surgery, Hallym University College of Medicine, Kangnam Sacred Heart Hospital, Seoul, Korea.
Department of Surgery, Hanyang University College of Medicine, Seoul, Korea.
Clin Mol Hepatol. 2015 Mar;21(1):7-13. doi: 10.3350/cmh.2015.21.1.7. Epub 2015 Mar 25.
Remarkable advances have been made recently in the area of liver regeneration. Even though liver regeneration after liver resection has been widely researched, new clinical applications have provided a better understanding of the process. Hepatic damage induces a process of regeneration that rarely occurs in normal undamaged liver. Many studies have concentrated on the mechanism of hepatocyte regeneration following liver damage. High mortality is usual in patients with terminal liver failure. Patients die when the regenerative process is unable to balance loss due to liver damage. During disease progression, cellular adaptations take place and the organ microenvironment changes. Portal vein embolization and the associating liver partition and portal vein ligation for staged hepatectomy are relatively recent techniques exploiting the remarkable progress in understanding liver regeneration. Living donor liver transplantation is one of the most significant clinical outcomes of research on liver regeneration. Another major clinical field involving liver regeneration is cell therapy using adult stem cells. The aim of this article is to provide an outline of the clinical approaches being undertaken to examine regeneration in liver diseases.
近年来肝脏再生领域取得了显著进展。尽管肝切除术后的肝脏再生已得到广泛研究，但新的临床应用使人们对这一过程有了更深入的了解。肝损伤会引发一种在正常未受损肝脏中很少发生的再生过程。许多研究都集中在肝损伤后肝细胞再生的机制上。晚期肝衰竭患者通常死亡率很高。当再生过程无法平衡肝损伤造成的损失时，患者就会死亡。在疾病进展过程中，会发生细胞适应性变化，器官微环境也会改变。门静脉栓塞以及联合肝脏分隔和门静脉结扎分期肝切除术是利用对肝脏再生认识的显著进展而出现的相对较新的技术。活体供肝移植是肝脏再生研究最重要的临床成果之一。另一个涉及肝脏再生的主要临床领域是使用成体干细胞的细胞治疗。本文旨在概述目前为研究肝脏疾病中的再生而采取的临床方法。
