National Institute of Allergy and Infectious Diseases, US National Institutes of Health, Bethesda, Maryland, USA.
Nat Med. 2010 Dec;16(12):1389-91. doi: 10.1038/nm1210-1389.
The immune system normally responds to influenza virus by making neutralizing antibodies to regions of the viral spike, the hemagglutinin, that vary year to year. This natural response protects against circulating subtypes but necessitates production of new vaccines annually. Newer vaccine approaches have succeeded in eliciting broadly neutralizing antibodies to highly conserved yet vulnerable regions of the hemagglutinin and suggest potential pathways for the development of universal influenza vaccines.
免疫系统通常通过针对病毒刺突（血凝素）中每年都发生变化的区域产生中和抗体来对流感病毒做出反应。这种自然反应可以预防流行的亚型，但需要每年生产新的疫苗。较新的疫苗方法已经成功地诱导出针对血凝素中高度保守但脆弱区域的广泛中和抗体，并为开发通用流感疫苗提供了潜在途径。
