HIV-1与流感抗体：以新方式识别抗原
HIV-1 and influenza antibodies: seeing antigens in new ways.
作者信息
Kwong Peter D, Wilson Ian A
机构信息
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.
出版信息
Nat Immunol. 2009 Jun;10(6):573-8. doi: 10.1038/ni.1746.
Abstract
New modes of humoral recognition have been identified by studies of antibodies that neutralize human immunodeficiency virus type 1 and influenza A viruses. Understanding how such modes of antibody-antigen recognition can occur in the context of sophisticated mechanisms of humoral evasion has implications for the development of effective vaccines. Here we describe eight modes of antibody recognition first observed with human immunodeficiency virus type 1. Similarities to four of these modes have been identified with antibodies to a conserved 'stem' epitope on influenza A viruses. We outline how each of these different modes of antibody recognition is particularly suited to overcoming a specific viral evasion tactic and assess potential routes of re-elicitation in vaccine settings.
摘要
通过对中和1型人类免疫缺陷病毒和甲型流感病毒的抗体研究，已确定了体液识别的新模式。了解这种抗体-抗原识别模式如何在复杂的体液免疫逃逸机制中发生，对开发有效的疫苗具有重要意义。在此，我们描述了首次在1型人类免疫缺陷病毒中观察到的八种抗体识别模式。已发现针对甲型流感病毒保守“茎”表位的抗体与其中四种模式具有相似性。我们概述了每种不同的抗体识别模式如何特别适合克服特定的病毒逃逸策略，并评估了疫苗环境中重新引发免疫反应的潜在途径。
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