Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia.
Int Orthop. 2011 Aug;35(8):1229-36. doi: 10.1007/s00264-010-1146-x. Epub 2010 Dec 7.
Current approaches for segmental bone defect reconstruction are restricted to autografts and allografts which possess osteoconductive, osteoinductive and osteogenic properties, but face significant disadvantages. The objective of this study was to compare the regenerative potential of scaffolds with different material composition but similar mechanical properties to autologous bone graft from the iliac crest in an ovine segmental defect model. After 12 weeks, in vivo specimens were analysed by X-ray imaging, torsion testing, micro-computed tomography and histology to assess amount, strength and structure of the newly formed bone. The highest amounts of bone neoformation with highest torsional moment values were observed in the autograft group and the lowest in the medical grade polycaprolactone and tricalcium phosphate composite group. The study results suggest that scaffolds based on aliphatic polyesters and ceramics, which are considered biologically inactive materials, induce only limited new bone formation but could be an equivalent alternative to autologous bone when combined with a biologically active stimulus such as bone morphogenetic proteins.
目前用于节段性骨缺损重建的方法仅限于具有骨传导性、骨诱导性和骨生成性的自体移植物和同种异体移植物，但它们存在明显的缺点。本研究的目的是比较不同材料组成但具有相似机械性能的支架与髂嵴自体骨移植物在羊节段性缺损模型中的再生潜力。12 周后，通过 X 射线成像、扭转试验、微计算机断层扫描和组织学分析对体内标本进行分析，以评估新形成骨的数量、强度和结构。在自体移植物组中观察到最高的新骨形成量和最高的扭矩值，而在医用级聚己内酯和磷酸三钙复合材料组中则观察到最低的新骨形成量。研究结果表明，基于脂肪族聚酯和陶瓷的支架被认为是生物惰性材料，仅能诱导有限的新骨形成，但当与骨形态发生蛋白等生物活性刺激物结合时，可作为自体骨的等效替代物。
