Department of Surgery, University of Missouri, Columbia, MO, USA.
Proteomics Clin Appl. 2007 Aug;1(8):845-52. doi: 10.1002/prca.200601005. Epub 2007 Jul 10.
Proteomic analysis of breast fluids has wide-ranging clinical applications. Protein expression in nipple aspirate fluid and breast cyst fluid may prove valuable for the detection and monitoring of breast cancer, but has been hampered by the lack of a single marker with sufficient breast cancer sensitivity and specificity to be clinically useful. The assessment of multiple proteins may offer a more powerful cancer detection tool. Breast cancer is particularly difficult to detect in women who are lactating. The identification of cancer predicting proteins in milk may prove very helpful in an early cancer detection in this group of women. A better understanding of the protein composition of milk and colostrum should improve infant care and nutrition, and lead to alternatives for individuals with milk allergies.
乳液的蛋白质组学分析具有广泛的临床应用。乳头吸出液和乳腺囊液中的蛋白质表达可能对乳腺癌的检测和监测具有重要价值，但由于缺乏单一的标志物具有足够的乳腺癌敏感性和特异性，使其在临床上难以应用。评估多种蛋白质可能提供更强大的癌症检测工具。对于哺乳期妇女，乳腺癌尤其难以检测。在这组女性中，鉴定乳汁中的癌症预测蛋白可能在早期癌症检测中非常有帮助。更好地了解乳汁和初乳的蛋白质组成，应该可以改善婴儿的护理和营养，并为牛奶过敏者提供替代选择。
