Proteome Informatics Group, Swiss Institute of Bioinformatics, Geneva, Switzerland.
Proteomics Clin Appl. 2007 Aug;1(8):900-15. doi: 10.1002/prca.200700188. Epub 2007 Jul 18.
On-line databases targeted towards protein contents in biological fluids are scarce. Consequently, the investigation of proteins identified in a biological fluid most importantly depends on crosschecking information gathered from less specific resources. This review summarises the key databases and tools for collecting information on tissue specificity or expression profiles. It also emphasises the high connectivity between databases fruitfully used to corroborate and piece information together. Finally, selected issues related to appropriate bioinformatics tools in the context of clinical applications are succinctly discussed.
针对生物体液中蛋白质含量的在线数据库很少。因此，对生物体液中鉴定出的蛋白质的研究最重要的是依赖于对从非特异性资源收集到的信息进行交叉核对。本文综述了用于收集组织特异性或表达谱信息的主要数据库和工具。还强调了数据库之间的高度连接性，这些数据库被有效地用于相互印证和整合信息。最后，简要讨论了与临床应用相关的适当生物信息学工具的一些问题。
