Division of Transfusion Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Proteomics Clin Appl. 2010 Dec;4(12):915-21. doi: 10.1002/prca.201000062.
Biomarkers have enormous potential to improve patient care by establishing tests of diagnosis, prognosis, and treatment effects. Successfully translating a biomarker from discovery to clinical application demands high-quality discovery research and high-quality clinical studies for biomarker validation; however, there are additional challenges that face biomarker research in pediatrics. There are also additional characteristics of pediatric medicine that make biomarker research especially needed. This review focuses on the fundamentals of biomarkers, the additional considerations needed for applying biomarker research to children, and recommendations for advancing pediatric biomarker research.
生物标志物具有通过建立诊断、预后和治疗效果的测试来改善患者护理的巨大潜力。成功地将生物标志物从发现转化为临床应用需要高质量的发现研究和高质量的临床研究来验证生物标志物；然而，儿科生物标志物研究还面临其他挑战。儿科医学还有其他特点，使得生物标志物研究尤为必要。这篇综述重点介绍了生物标志物的基本原理，以及将生物标志物研究应用于儿童所需的额外考虑因素，并为推进儿科生物标志物研究提出了建议。
