Institute of Molecular Medicine, Trinity College, University of Dublin, Dublin, Ireland.
Proteomics Clin Appl. 2010 Feb;4(2):215-27. doi: 10.1002/prca.200900145. Epub 2010 Jan 14.
Identification of the molecular mechanisms of host-pathogen interaction is becoming a key focus of proteomics. Analysis of these interactions holds promise for significant developments in the identification of new therapeutic strategies to combat infectious diseases, a process that will also benefit parallel improvements in molecular diagnostics, biomarker identification and drug discovery. This review highlights recent advances in functional proteomics initiatives in infectious disease with emphasis on studies undertaken within physiologically relevant parameters that enable identification of the infectious proteome rather than that of the vegetative state. Deciphering the molecular details of what constitutes physiologically relevant host-pathogen interactions remains an underdeveloped aspect of research into infectious disease. The magnitude of this deficit will be largely influenced by the ease with which model systems can be established to investigate such interactions. As the selective pressures exerted by the host on an infecting pathogen are numerous, the adequacy of certain model systems should be considered carefully.
鉴定宿主-病原体相互作用的分子机制正成为蛋白质组学的一个主要焦点。对这些相互作用的分析有望为识别新的治疗策略以对抗传染病带来重大进展，这一过程也将有益于分子诊断、生物标志物识别和药物发现的平行改进。本文重点介绍了传染病功能蛋白质组学研究的最新进展，强调了在生理相关参数下进行的研究，这些研究能够识别感染蛋白质组，而不是营养生长状态的蛋白质组。阐明构成生理相关宿主-病原体相互作用的分子细节仍然是传染病研究中一个欠发达的方面。这种缺陷的程度在很大程度上取决于建立模型系统来研究这些相互作用的难易程度。由于宿主对感染病原体施加的选择压力众多，因此应该仔细考虑某些模型系统的充分性。
