Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic.
Proteomics. 2011 Aug;11(15):3212-20. doi: 10.1002/pmic.201000767. Epub 2011 Jul 4.
The host-pathogen interaction represents a complex and dynamic biological system. The outcome of this interaction is dependent on the microbial pathogen properties to establish infection and the ability of the host to control infection. Although bacterial pathogens have evolved a variety of strategies to subvert host defense functions, several general mechanisms have been shown to be shared among these pathogens. As a result, host effectors that are critical for pathogen entry, survival and replication inside the host cells have become a new paradigm for antimicrobial targeting. This review focuses on the potential utility of a proteomics approach in defining the host-pathogen interaction from the host's perspective.
宿主-病原体相互作用代表了一个复杂而动态的生物系统。这种相互作用的结果取决于微生物病原体建立感染的特性和宿主控制感染的能力。尽管细菌病原体已经进化出多种策略来颠覆宿主防御功能，但已经证明这些病原体之间存在几种共同的机制。因此，宿主效应子对于病原体进入、在宿主细胞内生存和复制至关重要，成为了抗菌药物靶向的新范例。本综述重点介绍了从宿主角度定义宿主-病原体相互作用的蛋白质组学方法的潜在应用。
