Aldhalimi Muhsin A, Almuhanna Sadiq J, Alrikabi Samir H
Department of Dermatology, University of Kufa College of Medicine, Najaf, Iraq.
Skinmed. 2010 Jul-Aug;8(4):204-6.
Psoriasis is a chronic inflammatory and proliferative dermatosis. Previous studies have demonstrated that patients with psoriasis may have an increased risk of occlusive vascular disease. High serum lipid level has been suggested in the pathogenesis of this phenomenon. In this study, the authors assess the lipid profile in Iraqi patients with psoriasis and compare it with that of nonaffected persons. This study was designed and conducted as a cross-sectional study with 50 cases in the patient group and 50 patients in the control group. It was performed in the department of dermatology at Al-Sadr Teaching Hospital in Najaf, Iraq. The lipid profile, including serum levels of triglycerides, total cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein, were assessed in both groups. The patient and control groups each consisted of 39 men and 11 women. The serum triglyceride, cholesterol, LDL, and very LDL levels were significantly higher in psoriatic patients (P < .05) but not for high-density lipoprotein (P >.05). Serum lipid level was found to be significantly higher in Iraqi patients with psoriasis. It may be useful to do early screening and treatment ofhyperlipidemia in psoriasis to prevent atherosclerosis and its complications.
银屑病是一种慢性炎症性增殖性皮肤病。先前的研究表明,银屑病患者发生闭塞性血管疾病的风险可能增加。这种现象的发病机制中提示存在高血清脂质水平。在本研究中,作者评估了伊拉克银屑病患者的血脂谱,并将其与未患病者的血脂谱进行比较。本研究设计并开展为一项横断面研究,患者组有50例病例,对照组有50例患者。研究在伊拉克纳杰夫的萨德尔教学医院皮肤科进行。对两组患者的血脂谱进行评估,包括血清甘油三酯、总胆固醇、低密度脂蛋白(LDL)和高密度脂蛋白水平。患者组和对照组均由39名男性和11名女性组成。银屑病患者的血清甘油三酯、胆固醇、LDL和极低密度脂蛋白水平显著更高(P <.05),但高密度脂蛋白水平无显著差异(P >.05)。发现伊拉克银屑病患者的血清脂质水平显著更高。对银屑病患者进行高脂血症的早期筛查和治疗,以预防动脉粥样硬化及其并发症,可能是有益的。