Farshchian M, Zamanian A, Farshchian M, Monsef A R, Mahjub H
Department of Dermatology, Sina Hospital, Hamedan, Iran.
J Eur Acad Dermatol Venereol. 2007 Jul;21(6):802-5. doi: 10.1111/j.1468-3083.2006.02099.x.
Psoriasis is a common, chronic, inflammatory and proliferative skin disease associated with abnormal lipid metabolism. Previous studies have demonstrated that patients with psoriasis may have an increased risk of occlusive vascular disease.
The aim of this study was to determine lipid profile in Iranian patients with psoriasis.
A cross-sectional study was performed in 30 patients with approved psoriasis diagnosis attending the Dermatology Outpatient Department at Sina Hospital, Hamedan, Iran and 30 matched healthy individuals. Fasting blood sugar (FBS), triglyceride, cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL) and very low-density lipoprotein (VLDL) were measured using standard enzymatic method. The psoriasis activity was evaluated by psoriasis area and severity index (PASI Index).
FBS levels were higher in patients with psoriasis diagnosis but the differences were not significant (P-value = 0.284). There were no significant differences between serum levels of triglyceride and cholesterol in two groups. There were no differences in lipoproteins (HDL, LDL, VLDL) compared with control subjects. (P-value > 0.05) PASI Index and lipid profile did not have any significant correlation. The correlation between duration of disease and LDL were significant (P-value = 0.033).
Lipid profile in Iranian patients with psoriasis did not differ compared with control-matched subjects.
银屑病是一种常见的慢性炎症性增殖性皮肤病，与脂质代谢异常有关。先前的研究表明，银屑病患者发生闭塞性血管疾病的风险可能增加。
本研究旨在确定伊朗银屑病患者的血脂谱。
对伊朗哈马丹市锡纳医院皮肤科门诊确诊的30例银屑病患者及30例匹配的健康个体进行了一项横断面研究。采用标准酶法测定空腹血糖（FBS）、甘油三酯、胆固醇、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）和极低密度脂蛋白（VLDL）。通过银屑病面积和严重程度指数（PASI指数）评估银屑病的活动度。
确诊为银屑病的患者FBS水平较高，但差异无统计学意义（P值 = 0.284）。两组患者血清甘油三酯和胆固醇水平无显著差异。与对照组相比，脂蛋白（HDL、LDL、VLDL）无差异（P值>0.05）。PASI指数与血脂谱无显著相关性。疾病持续时间与LDL之间的相关性显著（P值 = 0.033）。
与匹配的对照组相比，伊朗银屑病患者的血脂谱无差异。
