旅行的高中生旅行团中发现有限的新型甲型 H1N1 流感感染。
Limited novel influenza A (H1N1) 09 infection in travelling high-school tour group.
机构信息
Hawke's Bay District Health Board, Hastings, New Zealand.
出版信息
Influenza Other Respir Viruses. 2011 Jan;5(1):47-51. doi: 10.1111/j.1750-2659.2010.00169.x.
BACKGROUND
A single case of novel influenza A (H1N1) 09 infection was identified by PCR among a New Zealand high-school group that toured California in April 2009. Close monitoring of the tour group and their New Zealand contacts identified 11 other tour members with respiratory symptoms who were investigated. In all nine instances where nasopharyngeal swabs were indicated, tests were negative for novel influenza A (H1N1) 09 by PCR.
OBJECTIVE
To determine whether serology could identify any cases of novel influenza A (H1N1) 09 that had not been detected by PCR.
METHODS
Acute and convalescent serological testing for antibodies against pandemic (H1N1) 2009 and seasonal A (H1N1) influenza viruses using haemagglutination inhibition assays and microneutralisation assays.
RESULTS
Serological analysis of symptomatic tour members identified a further possible case of novel influenza A (H1N1) 09 infection. The possible case had not been tested by PCR because he or she had already received prophylaxis with oseltamivir.
CONCLUSIONS
These findings suggest infection among tour group members was limited despite prolonged periods of close contact during travel. Furthermore, multiple public health interventions are likely to have effectively prevented an outbreak following the tour group's return.
背景
2009 年 4 月，新西兰一个高中旅行团在加利福尼亚旅行时，通过 PCR 发现了一例新型甲型流感（H1N1）09 感染病例。对旅行团及其新西兰接触者的密切监测发现，另外 11 名有呼吸道症状的旅行团成员也接受了调查。在所有 9 例需要进行鼻咽拭子检查的情况下，PCR 检测均为新型甲型流感（H1N1）09 阴性。
目的
确定血清学检测是否可以发现未通过 PCR 检测到的新型甲型流感（H1N1）09 病例。
方法
使用血凝抑制试验和微量中和试验对大流行性（H1N1）2009 年和季节性 A（H1N1）流感病毒的抗体进行急性和恢复期血清学检测。
结果
对有症状的旅行团成员进行血清学分析，发现了另一个可能的新型甲型流感（H1N1）09 感染病例。由于该患者已接受奥司他韦预防，因此未通过 PCR 进行检测。
结论
这些发现表明，尽管在旅行期间长时间密切接触，但旅行团成员的感染仍受到限制。此外，多项公共卫生干预措施可能有效地防止了旅行团返回后的疫情爆发。
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