Bouthoorn Selma H, van der Ploeg Tjeerd, van Erkel Nina E, van der Lely Nico
Department of Pediatrics, Reinier de Graaf Hospital, Delft, Netherlands.
Clin Pediatr (Phila). 2011 Mar;50(3):244-51. doi: 10.1177/0009922810388509. Epub 2010 Dec 6.
To investigate acute medical complications of alcohol intoxication among adolescents presenting to Reinier de Graaf Hospital, a major nonacademic hospital in Delft, the Netherlands.
The frequency of reduced consciousness, hypothermia, electrolyte disturbances, hypoglycemia, and acidosis along with alcohol intoxication was retrospectively studied in the medical records of patients aged 11 to 17 years admitted between January 1, 2000, and April 30, 2010.
Reduced consciousness (45%) and hypothermia (43.1%) were the most common clinical findings. More boys than girls experienced hypothermia (P = .028), probably because of the higher blood alcohol concentration level ( P = .026), which was associated with lower temperature (Pearson's r = -.37; P < .001). The most frequent electrolyte disturbance was hyperchloremia (31.1%), followed by low bicarbonate (22%), hypokalemia (11.9%), and hypernatremia (7.7%). Strikingly, none of the patients in this study suffered hypoglycemia. On the contrary, 13.6% of the patients were slightly hyperglycemic. Mild acidosis, both metabolic and respiratory, was observed among 28.8% of the patients, although the metabolic component predominated.
Acute medical complications because of alcohol intoxication appeared to be mild, and most remarkably none of the patients experienced hypoglycemia.
调查荷兰代尔夫特市一家大型非学术性医院——莱尼尔·德·格拉夫医院收治的青少年酒精中毒急性医学并发症情况。
回顾性研究2000年1月1日至2010年4月30日期间收治的11至17岁患者的病历,分析意识减退、体温过低、电解质紊乱、低血糖和酸中毒以及酒精中毒的发生频率。
意识减退(45%)和体温过低(43.1%)是最常见的临床表现。体温过低的男孩比女孩多(P = 0.028),可能是因为血液酒精浓度较高(P = 0.026),而血液酒精浓度与体温较低相关(皮尔逊相关系数r = -0.37;P < 0.001)。最常见的电解质紊乱是高氯血症(31.1%),其次是低碳酸氢盐血症(22%)、低钾血症(11.9%)和高钠血症(7.7%)。值得注意的是,本研究中没有患者发生低血糖。相反,13.6%的患者有轻度高血糖。28.8%的患者出现轻度酸中毒,包括代谢性和呼吸性酸中毒,不过以代谢性成分为主。
酒精中毒所致急性医学并发症似乎较轻,最显著的是没有患者发生低血糖。