Phlippoteau C, Brenot F, Blétry O, Simmonneau G, Duroux P
Service de Pneumo-Phtisiologie, Hôpital A.-Béclère, Clamart.
Rev Mal Respir. 1990;7(3):249-54.
An acute haemodynamic study was carried out prospectively in 6 patients fulfilling the diagnostic criteria of systemic sclerosis with pulmonary arterial hypertension. This study consisted of 7 baseline measurements and the effect of 6 drugs administered intravenously and known for their effects as vasodilators in the literature. These results were compared to those obtained on 44 patients suffering from pulmonary arterial hypertension previously studied at Hospital A.-Béclère. The prostacyclin (PGI2) possesses a very potent vasodilator effect, lowering the total pulmonary vascular resistance by 29% in patients suffering from scleroderma. As well as PGI2 phentolamine and hydralazine seemed to possess an acute vasodilator action which is certainly not negligible.
对6例符合系统性硬化症合并肺动脉高压诊断标准的患者进行了前瞻性急性血流动力学研究。该研究包括7次基线测量以及6种静脉给药药物的效果，这些药物在文献中以血管扩张剂著称。将这些结果与之前在A.-Béclère医院研究的44例肺动脉高压患者的结果进行了比较。前列环素（PGI2）具有非常强的血管扩张作用，可使硬皮病患者的总肺血管阻力降低29%。除了PGI2，酚妥拉明和肼屈嗪似乎也具有肯定不可忽视的急性血管扩张作用。
