前列环素对系统性硬化症继发肺动脉高压患者肺血流动力学的急性影响。
The acute effects of prostacyclin on pulmonary hemodynamics in patients with pulmonary hypertension secondary to systemic sclerosis.
作者信息
Menon N, McAlpine L, Peacock A J, Madhok R
机构信息
Glasgow Royal Infirmary University National Health Service Trust, Scotland, UK.
出版信息
Arthritis Rheum. 1998 Mar;41(3):466-9. doi: 10.1002/1529-0131(199803)41:3<466::AID-ART13>3.0.CO;2-O.
OBJECTIVE
To determine whether patients with isolated pulmonary hypertension secondary to systemic sclerosis (SSc) have a pulmonary vasculature that is responsive to treatment with vasodilators.
METHODS
Seven SSc patients with pulmonary hypertension underwent right heart catheterization. Pulmonary pressures and cardiac output were measured before and during a systemic intravenous infusion of prostacyclin.
RESULTS
Both pulmonary arterial mean pressure and pulmonary vascular resistance decreased significantly with prostacyclin infusion (median decrease 11% and 32%, respectively), with a concomitant increase in cardiac output (median increase 26%). No adverse hemodynamic effects were noted during the infusion.
CONCLUSION
Vasospasm contributes to the pulmonary hypertension complicating SSc. This feature may be amenable to treatment with vasodilators.
目的
确定继发于系统性硬化症（SSc）的孤立性肺动脉高压患者的肺血管系统是否对血管扩张剂治疗有反应。
方法
7例患有肺动脉高压的SSc患者接受了右心导管插入术。在系统性静脉输注前列环素之前和期间测量肺动脉压力和心输出量。
结果
输注前列环素后，肺动脉平均压和肺血管阻力均显著降低（中位数分别降低11%和32%），同时心输出量增加（中位数增加26%）。输注期间未观察到不良血流动力学效应。
结论
血管痉挛导致了SSc并发的肺动脉高压。这一特征可能适合用血管扩张剂治疗。
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