Seibold J R, Molony R R, Turkevich D, Ruddy M C, Kostis J B
J Rheumatol. 1987 Jun;14(3):519-24.
A selective antagonist of S2-serotonergic receptors, ketanserin, was administered intravenously during right heart catheterization to 14 patients with pulmonary hypertension complicating systemic sclerosis. A significant reduction in pulmonary vascular resistance was noted which was accompanied by an increase in cardiac output. Paradoxical increase of pulmonary artery pressure occurred in 3 patients, whereas 2 patients with mild pulmonary hypertension normalized both pulmonary pressure and vascular resistance. Our data support the hypothesis that serotonin, released during in vivo platelet activation, influences pulmonary vascular tone in systemic sclerosis.
在右心导管插入术期间，对14例合并系统性硬化症的肺动脉高压患者静脉注射了5-羟色胺2型（S2）血清素能受体的选择性拮抗剂酮色林。结果发现肺血管阻力显著降低，同时心输出量增加。3例患者出现肺动脉压反常升高，而2例轻度肺动脉高压患者的肺动脉压和血管阻力均恢复正常。我们的数据支持这样的假说，即在体内血小板激活过程中释放的血清素会影响系统性硬化症患者的肺血管张力。
