Yentzer Brad A, Ade Rachel A, Fountain Julie M, Clark Adele R, Taylor Sarah L, Borgerding Erika, Feldman Steven R
Department of Dermatology, Center for Dermatology Research, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1071, USA.
Cutis. 2010 Oct;86(4):208-13.
Variations in adherence may cause variations in treatment outcomes with topical corticosteroid therapy for atopic dermatitis. An intensive short course of outpatient treatment may promote good adherence and provide a high level of efficacy. The purpose of this study was to assess the efficacy, tolerability, and adherence to short-term treatment with fluocinonide cream 0.1% in the treatment of atopic dermatitis. Twenty participants with mild to severe atopic dermatitis were instructed to use fluocinonide cream 0.1% twice daily for 3 consecutive days for a total of 6 doses. Disease severity was assessed at baseline, day 3, day 7, and day 14. Electronic monitoring was used to measure adherence to treatment. Median adherence to treatment over the 3-day period was 100%. By day 14, the median visual analog scale (VAS) of pruritus and eczema area and severity index (EASI) scores improved from baseline by 79% and 76%, respectively. By the end of the study period, 11 participants had investigator global assessment (IGA) scores of clear or almost clear. The absolute degree of improvement was proportional to baseline disease severity. Short-term treatment with fluocinonide cream 0.1% for atopic dermatitis was well-tolerated and resulted in significant disease improvement (P < .001). Participants were highly adherent to the 3-day treatment regimen. Efforts to improve adherence may be valuable approaches for treating recalcitrant atopic dermatitis.
在特应性皮炎的外用糖皮质激素治疗中，用药依从性的差异可能导致治疗效果的差异。强化短期门诊治疗可能会提高依从性并提供较高的疗效。本研究的目的是评估0.1%氟轻松乳膏短期治疗特应性皮炎的疗效、耐受性和依从性。20名轻至重度特应性皮炎患者被指示连续3天每天使用0.1%氟轻松乳膏两次，共6剂。在基线、第3天、第7天和第14天评估疾病严重程度。使用电子监测来测量治疗依从性。3天治疗期间的中位治疗依从性为100%。到第14天，瘙痒的中位视觉模拟量表（VAS）以及湿疹面积和严重程度指数（EASI）评分分别较基线改善了79%和76%。到研究期结束时，11名参与者的研究者整体评估（IGA）评分为清除或几乎清除。改善的绝对程度与基线疾病严重程度成正比。0.1%氟轻松乳膏短期治疗特应性皮炎耐受性良好，并导致疾病显著改善（P <.001）。参与者对3天治疗方案的依从性很高。提高依从性的努力可能是治疗顽固性特应性皮炎的有价值方法。
