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季节性超急性全葡萄膜炎的概况与治疗结果

A profile and treatment outcome of seasonal hyper-acute panuveitis.

作者信息

Shrestha E

机构信息

Himalaya Eye Hospital, Pokhara, Nepal.

出版信息

Nepal J Ophthalmol. 2010 Jan-Jun;2(1):35-8. doi: 10.3126/nepjoph.v2i1.3702.

DOI:10.3126/nepjoph.v2i1.3702
PMID:21141325
Abstract

INTRODUCTION

Seasonal hyper-acute panuveitis (SHAPU) is a sight-threatening disease and its management is challenging.

OBJECTIVE

To study the profile and evaluate the visual outcome of the patients of clinically-diagnosed cases of SHAPU after treatment.

SUBJECTS AND METHODS

A retrospective interventional hospital-based study was carried out involving 21 subjects with clinically-diagnosed SHAPU. The data were retrieved from the record section of the hospital and analyzed. The variables studied were demographic pattern, clinical condition, duration of presentation and visual acuity before and after the treatment.

STATISTICS

The data were analyzed using Epi Info version 2000. Percentage prevalence, mean values with standard deviation, relative risk, 95% CI and p value were calculated. P value of < 0.05 was considered to be significant.

RESULTS

Among the 21 cases, the numbers of male and female were 11 (52.4 %) and 10 (46.7%) respectively. A comparative analysis of gender in children and adults did not show any significant difference (RR = 0.47, 95% CI = 0.22 - 1.01, Fisher exact test: p = 0.14). The mean for all ages was 7 +/- 12.68 years, while the mean age in pediatric cases was 4.5 +/- 3.91 years. Thirteen (61.9%) cases occurred in children below fifteen years. Fifteen (71.4%) cases reported during September and October. Presenting visual acuity of all cases was less than 3/60. All of them received medical treatment. By the end of the 41 week, seven (33.3%) patients regained vision to 6/18.

CONCLUSION

SHAPU is more prevalent in pediatric age group. It is equally prevalent among males and females. The visual acuity can improve with early medical treatment.

摘要

引言

季节性超急性全葡萄膜炎(SHAPU)是一种威胁视力的疾病,其治疗具有挑战性。

目的

研究临床诊断为SHAPU的患者经治疗后的特征并评估其视力预后。

对象与方法

开展了一项基于医院的回顾性干预研究,纳入21例临床诊断为SHAPU的患者。数据从医院病历科室获取并进行分析。所研究的变量包括人口统计学模式、临床状况、就诊时间以及治疗前后的视力。

统计学方法

使用Epi Info 2000软件对数据进行分析。计算患病率百分比、均值及标准差、相对风险、95%置信区间和p值。p值<0.05被认为具有统计学意义。

结果

21例患者中,男性11例(52.4%),女性10例(46.7%)。儿童与成人的性别比较分析未显示出任何显著差异(RR = 0.47,95% CI = 0.22 - 1.01,Fisher精确检验:p = 0.14)。所有年龄组的平均年龄为7±12.68岁,而儿科病例的平均年龄为4.5±3.91岁。13例(61.9%)病例发生在15岁以下儿童。15例(71.4%)病例在9月和10月报告。所有病例的就诊视力均低于3/60。他们均接受了药物治疗。在41周结束时,7例(33.3%)患者视力恢复至6/18。

结论

SHAPU在儿童年龄组中更为普遍。在男性和女性中患病率相当。早期药物治疗可改善视力。

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