Stanford University School of Medicine, Stanford, CA 94305-5484 , USA.
Biotechniques. 2005 Dec;39(6 Suppl):S14-25. doi: 10.2144/000112091.
The cell adhesion molecule integrin alphavbeta3 is an important player in the process of tumor angiogenesis and metastasis. Antibodies, peptides, peptidomimetics, and small molecule antagonists against integrin alphavbeta3 have been shown to induce endothelial apoptosis, to inhibit tumor angiogenesis, and to increase endothelial permeability. The ability to quantitatively image integrin alphavbeta3 expression in vivo in a noninvasive manner may shed new light into the mechanism of angiogenesis and antiangiogenic treatment efficacy based on integrin antagonism. Tumor integrin expression imaging will also aid in lesion detection, patient stratification, new anti-integrin drug development/validation, as well as treatment monitoring and optimization. This review summarizes the recent advances in multimodality imaging of tumor integrin alphavbeta3 expression using magnetic resonance imaging (MRI), ultrasound, near-infrared (NIR) fluorescence, single photon emission computed tomography (SPECT), and positron emission tomography (PET).
细胞黏附分子整合素 alphavbeta3 是肿瘤血管生成和转移过程中的重要参与者。已证实针对整合素 alphavbeta3 的抗体、肽、拟肽和小分子拮抗剂可诱导内皮细胞凋亡，抑制肿瘤血管生成，并增加内皮细胞通透性。以非侵入性方式定量成像体内整合素 alphavbeta3 表达的能力可能为基于整合素拮抗作用的血管生成和抗血管生成治疗效果的机制提供新的见解。肿瘤整合素表达成像也将有助于病灶检测、患者分层、新型抗整合素药物的开发/验证，以及治疗监测和优化。本综述总结了使用磁共振成像（MRI）、超声、近红外（NIR）荧光、单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET）对肿瘤整合素 alphavbeta3 表达进行多模态成像的最新进展。
