铜管促进的连续流动偶联和脱羧反应。

Continuous flow coupling and decarboxylation reactions promoted by copper tubing.

机构信息

Novartis Institutes for Biomedical Research Inc., Global Discovery Chemistry, 100 Technology Square, Cambridge, Massachusetts 02139, USA.

出版信息

Org Lett. 2011 Jan 21;13(2):280-3. doi: 10.1021/ol1026848. Epub 2010 Dec 8.

DOI:10.1021/ol1026848

PMID:21141809

Abstract

A convenient and efficient flow method for Ullmann condensations, Sonogashira couplings, and decarboxylation reactions using a commercially available copper tube flow reactor (CTFR) is described. The heated CTFR effects these transformations without added metals (e.g., Pd), ligands, or reagents, and in greater than 90% yield in most cases examined.

摘要

本文描述了一种使用市售的铜管流动反应器（CTFR）进行乌尔曼缩合反应、Sonogashira 偶联反应和脱羧反应的方便、高效的流动方法。在大多数情况下，加热的 CTFR 可以在无需添加金属（例如 Pd）、配体或试剂的情况下实现这些转化，并且产率大于 90%。