Emadi Seyed Naser, Kaffashi Mohammad, Poursaleh Zohreh, Akhavan-Moghaddam Jamal, Soroush Mohammad Reza, Emadi Seyed Emad, Taghavi Nez'hat-o-Sadat
Mazandaran University of Medical Sciences (MUMS), Sari, Iran.
Cutan Ocul Toxicol. 2011 Jun;30(2):170-4. doi: 10.3109/15569527.2010.539585. Epub 2010 Dec 10.
Sulfur mustard (SM) is a potent chemical warfare agent that was widely used during the First World War and the Iran-Iraq conflict. This vesicant agent causes several acute and chronic effects on the skin, eye, and respiratory system. We report the case of a 41-year-old man who was injured with SM in Iraq chemical attack in 1988. After exposure, he developed severe skin blisters on his upper trunk, dorsum of hands, and genitalia. Based on several clinical observations, such as atrophy, pigmentation, and vascular changes on genitalia with relevant findings in histopathological studies, persistent pigmentation, and damaged skin appendix in hand lesions, a diagnosis of "SM-induced poikiloderma" was postulated. The absence of any complication on the palmar aspect of hands is another remarkable finding in presented case, which suggests a plausible role of the palms as a vector for transporting SM to other sites of the skin.
硫芥是一种强效化学战剂，在第一次世界大战和两伊冲突期间被广泛使用。这种糜烂性毒剂会对皮肤、眼睛和呼吸系统造成多种急性和慢性影响。我们报告一例41岁男性病例，该患者于1988年在伊拉克化学袭击中被硫芥致伤。接触后，他的上躯干、手背和生殖器出现严重皮肤水疱。基于多项临床观察，如生殖器出现萎缩、色素沉着和血管变化，以及组织病理学研究中的相关发现，手部病变存在持续性色素沉着和皮肤附属器受损，推测诊断为“硫芥诱发的异色性皮病”。该病例另一个显著发现是手掌方面未出现任何并发症，这表明手掌作为将硫芥输送到皮肤其他部位的载体可能发挥了作用。
