Emadi Seyed Naser, Aslani Jafar, Poursaleh Zohreh, Izadi Morteza, Soroush Mohammadreza, Kafashi Mohammad, Alavinia Seyed Ali, Bakhshi Hossein, Karimi Amir, Momtaz-Manesh Kourosh, Babaei Ali Akbar, Esmaili Alireza, Raygan Babak, Emadi Seyed Emad, Babamahmoodi Farhang, Emadi Seyed Abolfazl
Skin Research Center, Mazandaran University of Medical Sciences, Sari, Iran.
Cutan Ocul Toxicol. 2012 Sep;31(3):214-9. doi: 10.3109/15569527.2011.641196. Epub 2011 Dec 21.
Iraq used chemical weapons against thousands of Iranian militaries and civilians. This study aimed to compare the chronic cutaneous side effects of exposure to sulfur mustard (SM) with nerve agents (NA).
The study enrolled 154 SM exposed cases and 175 (NA) exposed cases. Presence of any late cutaneous manifestations was evaluated by a dermatologist via prior history of acute cutaneous complications extracted from medical achieves.
only 18.1% mustard exposed group was asymptomatic compared to 62.4% nerve agent exposures. Mustard and non-mustard scars, intertrigo, xerosis, cherry angioma, hyper pigmentation, pilar keratosis, poikiloderma, and malignant tumors were significantly more frequent in mustard exposed patients (p < 0.05). Nerve agent exposed patients experienced significantly more frequent occurrence of acne a seborrheic dermatitis and tinea versicolor.
Mustard induced dermaltologic lesions were more common and specific than (NA) skin injuries. (NA) cause few psychocutaneous disorders like acne and seborrheic dermatitis in addition to psychological stress disorders.
伊拉克对数千名伊朗军事人员和平民使用了化学武器。本研究旨在比较接触硫芥（SM）与接触神经毒剂（NA）后的慢性皮肤副作用。
该研究纳入了154例接触SM的病例和175例接触NA的病例。皮肤科医生通过从医疗记录中提取的急性皮肤并发症既往史来评估是否存在任何晚期皮肤表现。
与62.4%接触神经毒剂的人群相比，接触硫芥的人群中仅18.1%无症状。接触硫芥的患者中，硫芥所致和非硫芥所致的瘢痕、擦烂、皮肤干燥、樱桃样血管瘤、色素沉着、毛发角化病、皮肤异色症和恶性肿瘤明显更为常见（p<0.05）。接触神经毒剂的患者中，寻常痤疮、脂溢性皮炎和花斑癣的发生率明显更高。
硫芥引起的皮肤病变比NA所致的皮肤损伤更常见且更具特异性。除心理应激障碍外，NA还会引发一些如寻常痤疮和脂溢性皮炎等精神皮肤疾病。
