Kesler Shelli R, Lacayo Norman J, Jo Booil
Department of Psychiatry and Behavioral Sciences, Stanford University, Palo Alto, CA, USA.
Brain Inj. 2011;25(1):101-12. doi: 10.3109/02699052.2010.536194.
Children with a history of cancer are at increased risk for cognitive impairments, particularly in executive and memory domains. Traditional, in-person cognitive rehabilitation strategies may be unavailable and/or impractical for many of these children given difficulties related to resources and health status. The feasibility and efficacy of implementing a computerized, home-based cognitive rehabilitation curriculum designed to improve executive function skills was examined in these children.
A one-arm open trial pilot study of an original executive function cognitive rehabilitation curriculum was conducted with 23 paediatric cancer survivors aged 7-19.
Compliance with the cognitive rehabilitation program was 83%, similar to that of many traditional programs. Following the cognitive intervention, participants showed significantly increased processing speed, cognitive flexibility, verbal and visual declarative memory scores as well as significantly increased pre-frontal cortex activation compared to baseline.
These results suggest that a program of computerized cognitive exercises can be successfully implemented at home in young children with cancer. These exercises may be effective for improving executive and memory skills in this group, with concurrent changes in neurobiologic status.
有癌症病史的儿童出现认知障碍的风险增加，尤其是在执行功能和记忆领域。鉴于资源和健康状况相关的困难，传统的面对面认知康复策略对许多此类儿童可能不可用和/或不切实际。在这些儿童中检验了实施旨在改善执行功能技能的计算机化家庭认知康复课程的可行性和有效性。
对23名7至19岁的儿科癌症幸存者进行了一项单臂开放试验性研究，该研究采用了原创的执行功能认知康复课程。
认知康复计划的依从率为83%，与许多传统计划相似。与基线相比，认知干预后，参与者的处理速度、认知灵活性、言语和视觉陈述性记忆分数显著提高，前额叶皮层激活也显著增加。
这些结果表明，计算机化认知练习程序可以在患有癌症的幼儿家中成功实施。这些练习可能对改善该组儿童的执行和记忆技能有效，同时神经生物学状态也会发生变化。
