Oprandi Maria Chiara, Oldrati Viola, Delle Fave Morena, Panzeri Daniele, Gandola Lorenza, Massimino Maura, Bardoni Alessandra, Poggi Geraldina
Neuro-Oncological and Neuropsychological Rehabilitation Unit, Scientific Institute, IRCCS E. Medea, Bosisio Parini, 23842 Lecco, Italy.
Department of Medical Oncology and Hematology, Pediatrics Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy.
Cancers (Basel). 2021 Sep 24;13(19):4776. doi: 10.3390/cancers13194776.
(1) Background: Brain tumor (BT) survivors show difficulties in the acquisition of developmental milestones, related to academic achievement, vocational employment, social relationships, and autonomy. The skills underlying adaptive functioning (AF) are usually damaged in BT survivors due to the presence of the brain tumor, treatment-related factors, and other neurological sequelae. In this study, we aimed to explore the contribution of different cognitive factors in children with BT to AF, considering diagnosis-related variables. (2) Methods: Standardized cognitive assessment was undertaken and clinical information was collected from a retrospective cohort of 78 children with a BT, aged between 6 and 18 year old at the time of the assessment. Regression models were computed to investigate the influence of the selected variables on daily functional skills as measured by the Functional Independence Measure for Children (WeeFIM). (3) Results: The analyses showed that the main explanatory variables are processing speed and time since diagnosis. Other clinical variables, such as age at diagnosis and hydrocephalus, differentially influence functional skills according to distinct domains (i.e., self-care, mobility, and cognition). (4) Conclusions: The main explanatory variables of AF that emerged in our models point to a potential target of improving AF management in pediatric BT survivors.
（1）背景：脑肿瘤（BT）幸存者在获取发育里程碑方面存在困难，这些困难与学业成绩、职业就业、社会关系和自主性有关。由于脑肿瘤的存在、治疗相关因素以及其他神经后遗症，适应性功能（AF）所依赖的技能在BT幸存者中通常会受到损害。在本研究中，我们旨在探讨诊断相关变量的情况下，BT患儿中不同认知因素对AF的影响。（2）方法：对78例BT患儿进行了标准化认知评估，并收集了临床信息，这些患儿在评估时年龄在6至18岁之间。计算回归模型以研究所选变量对儿童功能独立性测量量表（WeeFIM）所测量的日常功能技能的影响。（3）结果：分析表明，主要解释变量是处理速度和诊断后的时间。其他临床变量，如诊断时的年龄和脑积水，根据不同领域（即自我护理、移动和认知）对功能技能有不同影响。（4）结论：我们模型中出现的AF主要解释变量指出了改善小儿BT幸存者AF管理的潜在目标。
