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双胎妊娠中一胎胎膜在孕中期早期破裂的结局

Outcome of twin pregnancies complicated by early second trimester rupture of membranes in one sac.

作者信息

Zajicek Michal, Yagel Simcha, Ben-Ami Moshe, Weisz Boaz, Keselman Leandro, Lipitz Shlomo

机构信息

Department of Obstetrics and Gynecology affiliated with the Sackler School of Medicine, Tel Aviv University, The Chaim Sheba Medical Center, Tel Hashomer, Ramat Gan 52621, Israel.

出版信息

Twin Res Hum Genet. 2010 Dec;13(6):604-8. doi: 10.1375/twin.13.6.604.

Abstract

The aim of this study was to present the outcome of bichorionic twin pregnancies complicated by early second trimester rupture of membranes in one sac. Data regarding all cases of ruptured membranes at 13-20 weeks in bichorionic twin pregnancies were collected retrospectively from three fetal medicine units. Patients who have chosen to terminate the pregnancy were excluded from the study. Between January 2003 and July 2009, nine patients met inclusion criteria. Three out of nine couples decided on expectant management, and six preferred selective feticide. With expectant management one fetus died in utero and take home baby rate was 83% (5 of 6 fetuses), delivered at 27-32 weeks. When selective termination was performed, all non-reduced fetuses were born alive at 33-40 weeks. Two survivors of rupture of membranes had limb contractures, none had lung hypoplasia. One patient had clinical signs of amnionitis, which was ruled out later on pathological examination. Her post partum course was uncomplicated. Our data suggest that rupture of membranes in one sac of bichorionic twins at 13-20 weeks has favorable prognosis whether an intervention is preformed or not. Nonetheless, selective termination may have an advantage over expectant management, since gestational age at delivery was higher when selective termination was performed.

摘要

本研究的目的是呈现双绒毛膜双胎妊娠中一个羊膜囊在孕中期早期发生胎膜破裂的结局。从三个胎儿医学中心回顾性收集双绒毛膜双胎妊娠在13 - 20周时所有胎膜破裂病例的数据。选择终止妊娠的患者被排除在研究之外。2003年1月至2009年7月期间,有9名患者符合纳入标准。9对夫妇中有3对决定采取期待治疗,6对选择选择性减胎术。采取期待治疗时,1例胎儿死于宫内,活产率为83%(6例胎儿中的5例),于孕27 - 32周分娩。进行选择性终止妊娠时,所有未减灭的胎儿均在孕33 - 40周时存活出生。胎膜破裂的2名存活者有肢体挛缩,无一例有肺发育不全。1例患者有羊膜腔炎的临床体征,但后来病理检查排除。她的产后过程无并发症。我们的数据表明,双绒毛膜双胎在13 - 20周时一个羊膜囊发生胎膜破裂,无论是否进行干预,预后均良好。尽管如此,选择性终止妊娠可能比期待治疗更具优势,因为进行选择性终止妊娠时分娩孕周更大。

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