U.S. Naval Medical Research Unit 2, Jakarta, Indonesia.
Vector Borne Zoonotic Dis. 2011 Jun;11(6):709-13. doi: 10.1089/vbz.2010.0093. Epub 2010 Dec 13.
During febrile surveillance in the western Java City of Bandung, Indonesia, a patient with clinical symptoms consistent with hantavirus infection was found to have elevated titers of hantavirus-specific immunoglobulin M (IgM) and IgG antibodies. A subsequent epizoological investigation demonstrated a higher prevalence of hantavirus IgG antibodies in rodents trapped in the vicinity of the patient's home compared with rodents from a control area (13.2% vs. 4.7%, p = 0.036). The Old World Seoul hantavirus was detected by reverse transcriptase-polymerase chain reaction in the organs of 71% of the seropositive rodents tested. This is the first report of a Seoul virus infection in Indonesia supported by clinical, serological, and epizoological evidences. These findings suggest that hantavirus infection should be on the clinical differential diagnosis when acutely ill febrile patients report for care in western Java.
在印度尼西亚万隆市西爪哇的发热监测期间，发现一名具有符合汉坦病毒感染临床症状的患者的汉坦病毒特异性免疫球蛋白 M（IgM）和 IgG 抗体滴度升高。随后的流行病原学调查显示，与来自对照区域的啮齿动物相比，在患者家附近捕获的啮齿动物中汉坦病毒 IgG 抗体的流行率更高（13.2%对 4.7%，p=0.036）。通过逆转录-聚合酶链反应在 71%的血清阳性啮齿动物的器官中检测到旧世界首尔汉坦病毒。这是首次在印度尼西亚报告临床、血清学和流行病原学证据支持的首尔病毒感染。这些发现表明，当急性发热的患病患者在西爪哇寻求医疗时，汉坦病毒感染应在临床鉴别诊断中考虑。
