Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843, USA.
J Vet Intern Med. 2011 Jan-Feb;25(1):20-5. doi: 10.1111/j.1939-1676.2010.0644.x. Epub 2010 Dec 8.
The association between hypertriglyceridemia and pancreatitis remains obscure in dogs. A possible role of hypertriglyceridemia as a cause of pancreatitis in Miniature Schnauzers has been suspected.
HYPOTHESIS/OBJECTIVES: To compare serum triglyceride concentrations between Miniature Schnauzers with and without a recent history of pancreatitis.
Seventeen Miniature Schnauzers with a history of pancreatitis (group 1) and 34 age-matched Miniature Schnauzers without a history of pancreatitis (group 2) were prospectively enrolled.
Prospective case-control study. Two samples were collected from each of the 17 Miniature Schnauzers with pancreatitis: 1 during pancreatitis and 1 after clinical and biochemical resolution of pancreatitis. Serum triglyceride and cholesterol concentrations were compared between group 1 (after resolution of pancreatitis) and group 2.
Miniature Schnauzers in group 1 were significantly more likely to have hypertriglyceridemia (>108 mg/dL) (71%) after resolution of pancreatitis than Miniature Schnauzers in group 2 (33%; odds ratio = 5.02; 95% confidence interval = 1.4-17.8; P = .0163). Serum triglyceride concentrations were significantly higher in dogs of group 1 (median: 605.0 mg/dL) after resolution of pancreatitis than in dogs of group 2 (median: 73.5 mg/dL; P = .002).
Miniature Schnauzers with a history of pancreatitis were 5 times more likely to have hypertriglyceridemia than controls. Hypertriglyceridemia might be associated with the development of pancreatitis in some dogs of this breed. Additional studies are needed to further clarify the role of hypertriglyceridemia in the development of pancreatitis in Miniature Schnauzers as well as other dog breeds.
犬的高甘油三酯血症与胰腺炎之间的关系仍不清楚。有人怀疑高甘油三酯血症可能是迷你雪纳瑞患胰腺炎的一个原因。
假设/目的：比较有近期胰腺炎病史和无近期胰腺炎病史的迷你雪纳瑞的血清甘油三酯浓度。
17 只有胰腺炎病史的迷你雪纳瑞（第 1 组）和 34 只年龄匹配的无胰腺炎病史的迷你雪纳瑞（第 2 组）被前瞻性纳入。
前瞻性病例对照研究。从 17 只患有胰腺炎的迷你雪纳瑞中各采集 2 份样本：1 份在胰腺炎发作时，1 份在胰腺炎的临床和生化缓解后。比较第 1 组（胰腺炎缓解后）和第 2 组的血清甘油三酯和胆固醇浓度。
第 1 组的迷你雪纳瑞在胰腺炎缓解后更有可能出现高甘油三酯血症（>108 mg/dL）（71%），而第 2 组的迷你雪纳瑞只有 33%（优势比=5.02；95%置信区间=1.4-17.8；P=0.0163）。第 1 组的血清甘油三酯浓度在胰腺炎缓解后明显高于第 2 组（中位数：605.0 mg/dL）（中位数：73.5 mg/dL；P=0.002）。
有胰腺炎病史的迷你雪纳瑞发生高甘油三酯血症的可能性是对照组的 5 倍。高甘油三酯血症可能与某些该品种犬的胰腺炎发生有关。需要进一步的研究来进一步阐明高甘油三酯血症在迷你雪纳瑞和其他犬种胰腺炎发生中的作用。
