Division of Veterinary Clinical Science, Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush Veterinary Centre, Edinburgh, UK.
Equine Vet J. 2011 Jan;43(1):18-23. doi: 10.1111/j.2042-3306.2010.00108.x.
To correlate resting and exercising endoscopic grades of laryngeal function in horses undergoing high-speed treadmill endoscopy (HSTE) using the Havemeyer grading system. To correlate dorsal displacement of the soft palate (DDSP) seen at rest with palatal function during exercise.
Records of horses that underwent HSTE examination (1999-2009) were reviewed. Resting laryngeal function score and other abnormalities noted on resting endoscopy were recorded as were results of HSTE. Results of resting and exercising endoscopic findings were correlated.
281 horses underwent HSTE. There was significant correlation between grade of laryngeal function at rest (grades 1-4) and exercise (ρ=0.53, P<0.001) and between resting subgrades 3.1, 3.2 and 3.3 and exercising grades of laryngeal function (ρ=0.43, P=0.0017). DDSP was observed at rest significantly more often in horses that developed DDSP during HSTE than those without DDSP during HSTE (RR=4.1, P<0.001). The sensitivity and specificity of DDSP seen during resting endoscopy as a test for DDSP occurring during exercise were 25.5 and 95.1% respectively (positive predictive value 0.57, negative predictive value 0.83).
The results of the current study support the use of the Havemeyer system for grading laryngeal function in the resting horse, and corroborate findings of previous studies correlating resting and exercising palatal abnormalities. Studies that use the presence of spontaneous DDSP during resting endoscopic examination as an inclusion criterion for investigating efficacy of treatments for DDSP are likely to have a low proportion of horses with false positive diagnoses.
使用 Havemeyer 分级系统，对行高速跑步机内镜检查（HSTE）的马进行静息和运动时的喉功能内镜分级，以评估其相关性。评估静息时软腭背侧移位（DDSP）与运动时的腭功能的相关性。
回顾 1999-2009 年行 HSTE 检查的马的记录。记录静息内镜检查时的喉功能评分和其他异常，并记录 HSTE 的结果。将静息和运动内镜检查结果进行相关性分析。
281 匹马行 HSTE 检查。静息时（1-4 级）和运动时（ρ=0.53，P<0.001）的喉功能分级之间存在显著相关性，静息时的 3.1、3.2 和 3.3 亚级与运动时的喉功能分级之间存在显著相关性（ρ=0.43，P=0.0017）。与 HSTE 期间无 DDSP 的马相比，在 HSTE 期间发生 DDSP 的马在静息时更常观察到 DDSP（RR=4.1，P<0.001）。静息内镜检查时观察到的 DDSP 作为运动时发生 DDSP 的预测指标，其敏感性和特异性分别为 25.5%和 95.1%（阳性预测值 0.57，阴性预测值 0.83）。
本研究结果支持使用 Havemeyer 系统对静息马进行喉功能分级，并与以前的研究结果一致，这些研究结果表明静息和运动时的腭异常存在相关性。使用静息内镜检查时自发 DDSP 的存在作为研究 DDSP 治疗效果的纳入标准的研究，可能会导致假阳性诊断的马匹比例较低。
