β-谷甾醇对链脲佐菌素诱导的实验性高血糖的降血糖和抗氧化作用。
Antidiabetic and antioxidant potential of β-sitosterol in streptozotocin-induced experimental hyperglycemia.
机构信息
Reproductive Physiology Section, Centre for Advanced Studies, Department of Zoology, University of Rajasthan, Jaipur, India.
出版信息
J Diabetes. 2011 Mar;3(1):29-37. doi: 10.1111/j.1753-0407.2010.00107.x.
BACKGROUND
Oxidative stress, produced under diabetic conditions, may cause tissue damage. Although several drugs are currently available for the treatment of diabetes, their continued use may cause unwanted side effects. The aim of the present study was to evaluate the antioxidant potential of β-sitosterol (BS), a phytosterol from Solanum surattense, using an experimental model for diabetes-induced oxidative damage.
METHODS
The effects of 21 days treatment with BS (10, 15 and 20 mg/kg, p.o.) on blood, serum, and tissue biochemical parameters were evaluated in control and streptozotocin-induced diabetic rats. Nine experimental groups, including a control group, a diabetic group, and BS- and glibenclamide-treated diabetic groups, were evaluated.
RESULTS
All three dose levels dose dependently resulted in decreases in glycated hemoglobin, serum glucose, and nitric oxide, with concomitant increases in serum insulin levels. Furthermore, treatment with BS doses also increased pancreatic antioxidant levels, with a concomitant decrease in thiobarbituric acid-reactive substances.
CONCLUSIONS
β-Sitosterol has promising antidiabetic as well as antioxidant effects and may be considered in clinical studies for drug development.
背景
在糖尿病条件下产生的氧化应激可能会导致组织损伤。尽管目前有几种药物可用于治疗糖尿病，但它们的持续使用可能会引起不必要的副作用。本研究旨在评估β-谷甾醇（BS）的抗氧化潜力，BS 是一种来自 Solanum surattense 的植物甾醇，使用糖尿病诱导的氧化损伤实验模型进行评估。
方法
用 BS（10、15 和 20 mg/kg，po）治疗 21 天，评估其对正常和链脲佐菌素诱导的糖尿病大鼠的血液、血清和组织生化参数的影响。评估了 9 个实验组，包括对照组、糖尿病组和 BS 和格列本脲治疗的糖尿病组。
结果
所有三个剂量水平都表现出剂量依赖性地降低糖化血红蛋白、血清葡萄糖和一氧化氮，同时增加血清胰岛素水平。此外，BS 剂量的治疗还增加了胰腺的抗氧化水平，同时降低了硫代巴比妥酸反应物质。
结论
β-谷甾醇具有有前途的抗糖尿病和抗氧化作用，可考虑用于药物开发的临床研究。
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