Korean BioInformation Center (KOBIC), KRIBB, Daejeon, Korea.
BMC Genomics. 2010 Dec 2;11 Suppl 4(Suppl 4):S20. doi: 10.1186/1471-2164-11-S4-S20.
Aging is a complex and challenging phenomenon that requires interdisciplinary efforts to unravel its mystery. Insight into genes relevant to the aging process would offer the chance to delay and avoid some of deteriorative aspects of aging through the use of preventive methods. To assist basic research on aging, a comprehensive database and analysis platform for aging-related genes is required.
We developed a web-based database server, called Gerontome that contains aging-related gene information and user-friendly analysis pipelines. To construct the Gerontome database, we integrated aging-related genes and their annotation data. The aging-related genes were categorized by a set of structural terms from Gene Ontology (GO). Analysis pipelines for promoter analysis and protein-ligand docking were developed. The promoter analysis pipeline allows users to investigate the age-dependent regulation of gene expression. The protein-ligand docking pipeline provides information on the position and orientation of a ligand in an age-related protein surface.
Gerontome can be accessed through web interfaces for querying and browsing. The server provides comprehensive age-related gene information and analysis pipelines. Gerontome is available free at http://gerontome.kobic.re.kr.
衰老是一个复杂且具有挑战性的现象，需要跨学科的努力来揭开其奥秘。深入了解与衰老过程相关的基因，将有机会通过使用预防方法来延缓和避免衰老的一些恶化方面。为了辅助衰老的基础研究，需要一个包含与衰老相关基因的综合数据库和分析平台。
我们开发了一个基于网络的数据库服务器，称为 Gerontome，其中包含与衰老相关的基因信息和用户友好的分析管道。为了构建 Gerontome 数据库，我们整合了与衰老相关的基因及其注释数据。这些与衰老相关的基因是根据来自基因本体论 (GO) 的一组结构术语进行分类的。我们还开发了启动子分析和蛋白质-配体对接分析的管道。启动子分析管道允许用户研究基因表达的年龄依赖性调节。蛋白质-配体对接管道提供了关于配体在与年龄相关的蛋白质表面上的位置和方向的信息。
Gerontome 可以通过网络界面进行查询和浏览。该服务器提供了全面的与年龄相关的基因信息和分析管道。Gerontome 可在 http://gerontome.kobic.re.kr 免费获取。
