细菌胞质分裂：FzlA 使 FtsZ 丝束卷曲以产生分裂力。
Bacterial cytokinesis: FzlA frizzes FtsZ filaments for fission force.
机构信息
Department of Microbiology and Molecular Genetics, University of Texas Medical School at Houston, 6431 Fannin Street, Houston, TX 77030, USA.
出版信息
Curr Biol. 2010 Dec 7;20(23):R1024-7. doi: 10.1016/j.cub.2010.10.052.
Abstract
Most bacteria divide by assembling filaments of the tubulin-like protein FtsZ into a cytokinetic ring, which then constricts. A recent study suggests that Caulobacter crescentus uses a novel regulator, FzlA, to activate ring constriction by inducing helical bundles of FtsZ filaments.
摘要
大多数细菌通过将类似微管蛋白的 FtsZ 蛋白装配成细胞分裂环，然后进行收缩来进行分裂。最近的一项研究表明，新月柄杆菌利用一种新型调节剂 FzlA 通过诱导 FtsZ 丝的螺旋束来激活环的收缩。
相似文献
1
Bacterial cytokinesis: FzlA frizzes FtsZ filaments for fission force.细菌胞质分裂：FzlA 使 FtsZ 丝束卷曲以产生分裂力。
Curr Biol. 2010 Dec 7;20(23):R1024-7. doi: 10.1016/j.cub.2010.10.052.
2
FzlA, an essential regulator of FtsZ filament curvature, controls constriction rate during Caulobacter division.FzlA 是 FtsZ 丝弯曲的必需调节剂，控制着钙杆菌分裂过程中的缢缩速率。
Mol Microbiol. 2018 Jan;107(2):180-197. doi: 10.1111/mmi.13876. Epub 2017 Dec 1.
3
Short FtsZ filaments can drive asymmetric cell envelope constriction at the onset of bacterial cytokinesis.短的FtsZ丝可以在细菌胞质分裂开始时驱动不对称的细胞包膜收缩。
EMBO J. 2017 Jun 1;36(11):1577-1589. doi: 10.15252/embj.201696235. Epub 2017 Apr 24.
4
FtsA Regulates Z-Ring Morphology and Cell Wall Metabolism in an FtsZ C-Terminal Linker-Dependent Manner in Caulobacter crescentus.FtsA 通过依赖于 FtsZ C 端连接子的方式调节 Z 环形态和细胞壁代谢在新月柄杆菌中。
J Bacteriol. 2020 Mar 11;202(7). doi: 10.1128/JB.00693-19.
5
The intrinsically disordered C-terminal linker of FtsZ regulates protofilament dynamics and superstructure .FtsZ蛋白内在无序的C末端连接子调控原丝动力学和超结构。
J Biol Chem. 2017 Dec 15;292(50):20509-20527. doi: 10.1074/jbc.M117.809939. Epub 2017 Oct 31.
6
Organization of FtsZ filaments in the bacterial division ring measured from polarized fluorescence microscopy.从偏振荧光显微镜测量的细菌分裂环中 FtsZ 丝的组织。
Biophys J. 2013 Nov 5;105(9):1976-86. doi: 10.1016/j.bpj.2013.09.030.
7
An Essential Regulator of Bacterial Division Links FtsZ to Cell Wall Synthase Activation.细菌分裂的必需调节剂将 FtsZ 与细胞壁合成酶的激活联系起来。
Curr Biol. 2019 May 6;29(9):1460-1470.e4. doi: 10.1016/j.cub.2019.03.066. Epub 2019 Apr 25.
8
FtsZ in bacterial cytokinesis: cytoskeleton and force generator all in one.细菌胞质分裂中的 FtsZ：细胞骨架和力发生器合二为一。
Microbiol Mol Biol Rev. 2010 Dec;74(4):504-28. doi: 10.1128/MMBR.00021-10.
9
At the Heart of Bacterial Cytokinesis: The Z Ring.细菌胞质分裂的核心：Z 环。
Trends Microbiol. 2019 Sep;27(9):781-791. doi: 10.1016/j.tim.2019.04.011. Epub 2019 Jun 3.
10
Imaging-based identification of a critical regulator of FtsZ protofilament curvature in Caulobacter.基于成像的研究鉴定了柄杆菌 FtsZ 原丝曲率的关键调控因子。
Mol Cell. 2010 Sep 24;39(6):975-87. doi: 10.1016/j.molcel.2010.08.027.
本文引用的文献
1
Molecular mechanism by which the nucleoid occlusion factor, SlmA, keeps cytokinesis in check.核质区隔因子 SlmA 抑制细胞分裂的分子机制。
EMBO J. 2011 Jan 5;30(1):154-64. doi: 10.1038/emboj.2010.288. Epub 2010 Nov 26.
2
Imaging-based identification of a critical regulator of FtsZ protofilament curvature in Caulobacter.基于成像的研究鉴定了柄杆菌 FtsZ 原丝曲率的关键调控因子。
Mol Cell. 2010 Sep 24;39(6):975-87. doi: 10.1016/j.molcel.2010.08.027.
3
In vivo structure of the E. coli FtsZ-ring revealed by photoactivated localization microscopy (PALM).活细胞中由光激活定位显微镜（PALM）揭示的大肠杆菌 FtsZ 环的结构。
PLoS One. 2010 Sep 13;5(9):e12682. doi: 10.1371/journal.pone.0012680.
4
Curved FtsZ protofilaments generate bending forces on liposome membranes.弯曲的FtsZ原丝在脂质体膜上产生弯曲力。
EMBO J. 2009 Nov 18;28(22):3476-84. doi: 10.1038/emboj.2009.277. Epub 2009 Sep 24.
5
Bacterial cell division: assembly, maintenance and disassembly of the Z ring.细菌细胞分裂：Z环的组装、维持与解体
Nat Rev Microbiol. 2009 Sep;7(9):642-53. doi: 10.1038/nrmicro2198.
6
Modeling the physics of FtsZ assembly and force generation.模拟FtsZ组装和力产生的物理过程。
Proc Natl Acad Sci U S A. 2009 Jun 9;106(23):9238-43. doi: 10.1073/pnas.0902258106. Epub 2009 May 28.
7
Adenine nucleotide-dependent regulation of assembly of bacterial tubulin-like FtsZ by a hypermorph of bacterial actin-like FtsA.细菌肌动蛋白样FtsA的超形态对细菌微管蛋白样FtsZ组装的腺嘌呤核苷酸依赖性调控。
J Biol Chem. 2009 May 22;284(21):14079-86. doi: 10.1074/jbc.M808872200. Epub 2009 Mar 17.
8
SepF increases the assembly and bundling of FtsZ polymers and stabilizes FtsZ protofilaments by binding along its length.SepF增加FtsZ聚合物的组装和捆绑，并通过沿其长度结合来稳定FtsZ原丝。
J Biol Chem. 2008 Nov 7;283(45):31116-24. doi: 10.1074/jbc.M805910200. Epub 2008 Sep 9.
9
Reconstitution of contractile FtsZ rings in liposomes.在脂质体中重建收缩性FtsZ环。
Science. 2008 May 9;320(5877):792-4. doi: 10.1126/science.1154520. Epub 2008 Apr 17.
10
The structure of FtsZ filaments in vivo suggests a force-generating role in cell division.FtsZ丝在体内的结构表明其在细胞分裂中具有产生力的作用。
EMBO J. 2007 Nov 14;26(22):4694-708. doi: 10.1038/sj.emboj.7601895. Epub 2007 Oct 18.
Zotero 插件